Evidence map›Paper›PMID 41882368›Full record

ArticleNature2026

Dominant clones leverage developmental epigenomic states to drive ependymoma.

Alisha S Kardian, Hua Sun, Siri Ippagunta, Nicholas Laboe, Srinidhi Varadharajan, Kwanha Yu, Hsiao-Chi Chen, Erik Emanus, Tuyu Zheng, Riley M Deneen and 38 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Alisha S Kardian *Center of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Hua Sun *Center of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Siri IppaguntaCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Nicholas LaboeCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Srinidhi VaradharajanCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-2033-0758
Kwanha YuCell and Gene Therapy Program, Baylor College of Medicine, Houston, TX, USA.
Hsiao-Chi ChenCell and Gene Therapy Program, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-7505-6119
Erik EmanusCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Tuyu ZhengCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-3385-7353
Riley M DeneenCell and Gene Therapy Program, Baylor College of Medicine, Houston, TX, USA.
Jon P ConnellyCenter for Advanced Genome Engineering, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-5564-1775
Yong-Dong WangCenter for Advanced Genome Engineering, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0001-8751-9216
Jiangshan ZhanDepartment of Pediatrics, Section of Neurology, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0002-3836-8332
Hengxi LiuCancer and Cell Biology Program, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0009-0002-8337-638X
Kimberley LoweDepartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Taylor BugbeeCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Rakesh PathakCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Amanda BlandCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Sanya MehtaCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Sophie CochioloCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Amir ArabzadeCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Blake HolcombCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Kaitlin M BuddCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Gabriele KembuanCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-4706-3573
Tristen WrightCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Emma CaesarCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Maxwell ParkCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.
Amelia HancockUniversity of Bath, Bath, UK.
David GeeUniversity of Bath, Bath, UK.
Joel MurdochUniversity of Bath, Bath, UK.
Yi XiaoChildren's Medical Center Research Institute, UT Southwestern, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-3817-3471
Samuel K McBrayerChildren's Medical Center Research Institute, UT Southwestern, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-9361-675X
Thomas E MerchantRadiation Oncology Department, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-0412-6255
Jun QiCancer Biology Department, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1461-3356
Adam D DurbinDivision of Molecular Oncology, Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-5472-9847
Lindsay A SchwarzDepartment of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN, USA.
Li WangDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9510-6294
Andrew M DonsonDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Nicholas K ForemanDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Sameer AgnihotriDepartment of Neurological Surgery, University of Pittsburg, Pittsburg, PA, USA.
Alfonso LavadoDepartment of Cell and Molecular Biology, St Jude Children's Research Hospital, Memphis, TN, USA.
Suzanne J BakerCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-5833-472X
David W EllisonDepartment of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-1239-7757
Hyun Kyoung LeeCancer and Cell Biology Program, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-5793-4398
Shondra M Pruett-MillerCenter for Advanced Genome Engineering, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-3793-585X
Kelsey C BertrandDepartment of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA. kelsey.bertrand@stjude.org.
Benjamin DeneenCancer and Cell Biology Program, Baylor College of Medicine, Houston, TX, USA. deneen@bcm.edu.ORCID http://orcid.org/0000-0002-6335-1081
Stephen C MackCenter of Excellence in Neuro-Oncology Sciences, St Jude Children's Research Hospital, Memphis, TN, USA. stephen.mack@stjude.org.ORCID http://orcid.org/0000-0001-9620-4742

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
The DNA Damage Response and Tumorigenesis in the BrainP01CA096832 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BAKER, SUZANNE J. · 2003 to 2025
$38.0M
LAMPSP01CA298963 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI RICHARD W KRIWACKI, Charles G Mullighan · 2025 to 2026
$9.1M
Integrative bioinformatics and functional characterization of oncogenic driver aberrations in cancerU01CA217842 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DENEEN, BENJAMIN, MILLS, GORDON B. · 2017 to 2021
$3.6M
Systematic Characterization and Targeting of Neomorphic Drivers in CancerU01CA281902 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Benjamin Deneen, Han Liang · 2023 to 2026
$3.5M
MOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMAR01CA223388 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DENEEN, BENJAMIN, NOEBELS, JEFFREY · 2018 to 2022
$3.5M
Astrocyte Transcriptional Dependencies in Brain CircuitsR35NS132230 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Benjamin Deneen · 2023 to 2026
$3.5M
Deciphering the mechanisms of glia development and white matter injuryR01NS110859 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Hyun Kyoung Lee · 2019 to 2026
$3.2M
Targeting tumor and T cell DNA methylomes to improve CAR T cell therapies for diffuse midline gliomaU01CA281823 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Giedre Krenciute, Stephen C Mack · 2023 to 2026
$2.8M
Role of FACT in ZFTA-RelA fusion driven ependymomaR01CA280203 · NCI · OHIO STATE UNIVERSITY · PI Stephen C Mack, Monica Venere · 2023 to 2026
$2.8M
Deciphering the Role of Aberrant Endogenous Retroviral Expression in Onco-histone Driven GliomaR01NS116361 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Stephen C Mack · 2021 to 2026
$2.5M
Transcriptional Regulation in ZFTA-RELA EpendymomaR01CA284455 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Benjamin Deneen, Stephen C Mack · 2023 to 2026
$2.5M
NCI NIH HHS F31 CA265285NCI NIH HHS K99 CA277576NCI NIH HHS P01 CA096832NCI NIH HHS P01 CA298963NCI NIH HHS P30 CA021765NCI NIH HHS R01 CA223388NCI NIH HHS R01 CA280203NCI NIH HHS R01 CA284455NCI NIH HHS U01 CA217842NCI NIH HHS U01 CA281823NCI NIH HHS U01 CA281902NCI NIH HHS U01 CA294103NINDS NIH HHS R01 NS110859NINDS NIH HHS R01 NS116361NINDS NIH HHS R01 NS124093NINDS NIH HHS R01 NS126287NINDS NIH HHS R35 NS132230
6 · The paper itself

Abstract

ZFTA-RELA is the most recurrent genetic alteration seen in paediatric supratentorial ependymoma (EPN) and is sufficient to initiate tumours in mice

Indexed as

Cell Transformation, NeoplasticEpendymomaEpigenomeSupratentorial NeoplasmsAnimalsCell DifferentiationCell LineageChromatinClone CellsDNA-Binding ProteinsEpigenomicsFemaleHumansMaleMiceOncogene Proteins, FusionChromatinDNA-Binding ProteinsOncogene Proteins, FusionTranscription Factors

Identifiers

PMID41882368
PMCPMC13102692

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.