Evidence map›Paper›PMID 41882360›Full record

ArticleNature2026

Structural basis of supercoiling-induced CRISPR-Cas9 off-target activity.

Quentin M Smith, Sylvia Whittle, Ricardo J Aramayo, Daniel E Rollins, Adam S B Jalal, Deborah I Egharevba, Kyle L Morris, Alice L B Pyne, David S Rueda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Quentin M SmithMRC Laboratory of Medical Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-2967-9240
Sylvia WhittleDepartment of Materials Science and Engineering, University of Sheffield, Sheffield, UK.ORCID http://orcid.org/0009-0008-9164-9513
Ricardo J AramayoMRC Laboratory of Medical Sciences, Imperial College London, London, UK.
Daniel E RollinsDepartment of Materials Science and Engineering, University of Sheffield, Sheffield, UK.
Adam S B JalalDepartment of Infectious Disease, Imperial College London, London, UK.
Deborah I EgharevbaMRC Laboratory of Medical Sciences, Imperial College London, London, UK.ORCID http://orcid.org/0009-0007-5650-7790
Kyle L MorrisWellcome Genome Campus, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID http://orcid.org/0000-0002-1717-8134
Alice L B PyneDepartment of Materials Science and Engineering, University of Sheffield, Sheffield, UK. a.l.pyne@sheffield.ac.uk.ORCID http://orcid.org/0000-0002-2658-8987
David S RuedaMRC Laboratory of Medical Sciences, Imperial College London, London, UK. david.rueda@imperial.ac.uk.ORCID http://orcid.org/0000-0003-4657-6323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CRISPR-Cas9 is a powerful genome-editing tool

Indexed as

CRISPR-Associated Protein 9CRISPR-Cas SystemsDNA, SuperhelicalGene EditingCryoelectron MicroscopyDNA, CircularModels, MolecularProtein DomainsRNARNA, Guide, CRISPR-Cas SystemsCRISPR-Associated Protein 9DNA, CircularDNA, SuperhelicalRNARNA, Guide, CRISPR-Cas Systems

Identifiers

PMID41882360
PMCPMC13171457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.