ArticleNature2026
Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Machine learning and computational approaches to model therapeutic response and resistance in diffuse midline glioma.Journal of neuro-oncology · 2026Review
- A proteogenomic RNA processing mechanism drives sex differences in meningioma.Research square · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
86 authors.
Jiao Zhang *Texas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA. jiao.zhang@bcm.edu.ORCID 0000-0001-8218-3688
Winnie Ong *The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Alexandra Rasnitsyn *The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Ricardo Daniel GonzalezTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-2549-8138
Rodrigo Lopez GutierrezDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID 0009-0008-5413-3286
Polina BalinTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Amr SaadeldinTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Xiaochong WuTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Maria C VladoiuThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-8644-0581
Vicente Santa-Maria LopezTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Fernando Gonzalez-SalinasTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-7590-0869
Navneesh YadavDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Dinesh MohanakrishnanDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kannan Boosi Narayana RaoDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Raja Gopal Reddy MooliDivision of Metabolism and Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Hinda NajemDepartment of Neurological Surgery, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-4432-9708
Sebastian PachecoDepartment of Neurological Surgery, Northwestern University, Chicago, IL, USA.
Kaitlin KharasThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Cory RichmanThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
David PrzelickiThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Evan Y WangThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-7984-3147
Haipeng SuTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Rachel Naomi CurryTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Runze YangSection of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
Michelle Masayo Kameda-SmithTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Bryn LivingstonThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-4947-0081
David ScottThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Zaili LuoDepartment of Pediatrics, Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
Mingyang XiaKey Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China.
Namal AbeysundaraThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Anders W EricksonThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-6134-7812
Ncedile MankahlaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Lucas ZhongMing HuDepartment of Systems Biology, Columbia University Medical Center, New York, NY, USA.
Chu PanPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Raul SuarezThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Ning HuangTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Yihao WuTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0003-0163-8009
Hao WangThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Tajana DouglasThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Jonelle PallotaThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Steven HébertDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-6267-8595
Karen NgPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.ORCID 0009-0007-2217-3446
Krystin MantioneDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Heather WhetstoneThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Hassaan MaanDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Hussein LakkisDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Juyeun LeeCase Comprehensive Cancer Center, Cleveland, OH, USA.ORCID 0000-0001-8276-5020
Sadeesh K RamakrishnanDivision of Metabolism and Endocrinology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Yanxin PeiCenter for Cancer and Immunology, Brain Tumor Institute, Children's National Hospital, Washington, DC, USA.
Yujie TangKey Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Key Laboratory of Reproductive Medicine, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-7647-5780
Frank Y LinTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Guillermo AldaveDepartment of Neurosurgery, Texas Children's Hospital, Houston, TX, USA.
Marco GalloTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-8451-8207
Robert M FriedlanderDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-5008-7592
Faiyaz NottaDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Laura K DonovanThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Murali ChintagumpalaTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Bo WangDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Yun LiDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-5849-5910
Daniel D De CarvalhoDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Zhaolei ZhangDepartment of Computer Science, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-7303-6472
Ying MaoDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0001-8055-115X
Wei HuaDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Charles EberhartDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.
Calixto-Hope G LucasDepartment of Pathology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-8347-9592
Sriram VennetiLaboratory of Brain Tumor Metabolism and Epigenetics, Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Poul H SorensenDepartment of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.ORCID 0000-0001-7447-2199
Alberto DelaidelliDepartment of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.
Hao LiDepartment of Neurosurgery, Children's Hospital of Fudan University, Shanghai, China.ORCID 0000-0001-7755-1749
Wenhao ZhouGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.ORCID 0000-0001-8956-7238
Jason KirkDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
Dean G TangDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.ORCID 0000-0001-5029-1174
Tao JiangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-8529-4487
Hailong LiuChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-6181-2577
Justin D LathiaCase Comprehensive Cancer Center, Cleveland, OH, USA.ORCID 0000-0003-3168-7290
Hiromichi SuzukiDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.ORCID 0000-0002-8858-0294
Jeremy N RichUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-7845-5302
Lincoln D SteinDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Nada JabadoDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-2485-3692
Vijay RamaswamyThe Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-6557-895X
Q Richard LuBrain Tumor Center, Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-6846-9014
Amy B HeimbergerDepartment of Neurological Surgery, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-9970-8695
Craig DanielsTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.
Kulandaimanuvel Antony MichealrajDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. micheala@pitt.edu.ORCID 0000-0002-3967-0816
Claudia L KleinmanDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada. claudia.kleinman@mcgill.ca.ORCID 0000-0002-5158-7126
Michael D TaylorTexas Children's Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA. mdt.cns@gmail.com.ORCID 0000-0001-7009-3466
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9MTropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo, FREDERICK F LANG · 2008 to 2026
$41.2MMouse models to discover new drivers of medulloblastomaR01CA159859 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael D. Taylor, WILLIAM A WEISS · 2011 to 2026
$10.4MCCL2 and CCR2 as metastatic drivers and therapeutic targets in medulloblastomaR01CA255369 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GARZIA, LIVIA, TAYLOR, MICHAEL D. · 2021 to 2025
$3.9MTargeting integrated metabolic and epigenetic pathways in childhood ependymomasR01CA261926 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Deepak Nagrath, Benita Tamrazi · 2022 to 2026
$3.0MPrevention and treatment of lethal metastases in group 3 medulloblastomaR01NS106155 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TAYLOR, MICHAEL D., WEISS, WILLIAM A · 2018 to 2022
$2.8MUnravelling metabolic dependencies in H3K27M mutant DIPGR01NS110572 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sriram Venneti · 2019 to 2026
$2.7MTargeting metabolic dependencies in ZFTA-RELA fusion childhood ependymomasR01NS127799 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sriram Venneti · 2023 to 2026
$1.8MGlial Origin and Signaling in MedulloblastomaR01NS140460 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI QING Richard LU, Mei Xin · 2025 to 2026
$1.2MHigh Memory High-Performance Computer Cluster for Biomedical ResearchS10OD032185 · OD · BAYLOR COLLEGE OF MEDICINE · PI HILSENBECK, SUSAN G. · 2022 to 2022
$596kNCI NIH HHS P30 CA047904NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA127001NCI NIH HHS R01 CA159859NCI NIH HHS R01 CA255369NCI NIH HHS R01 CA261926NIH HHS S10 OD032185NINDS NIH HHS R01 NS106155NINDS NIH HHS R01 NS110572NINDS NIH HHS R01 NS127799NINDS NIH HHS R01 NS140460
Abstract
Posterior fossa type A (PFA) ependymoma is an unusual infantile brain tumour with few known somatic mutations, thought to be driven by epigenetic mechanisms
Indexed as
AndrogensBrain NeoplasmsEpendymomaRhombencephalonAndrogen AntagonistsAnimalsCell DifferentiationCell ProliferationDisease Models, AnimalFemaleHumansMaleMiceReceptors, AndrogenSex CharacteristicsSignal TransductionAndrogen AntagonistsAndrogensReceptors, Androgen
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.