Evidence map›Paper›PMID 41882357›Full record

ArticleNature2026

Parasites trigger epithelial cell crosstalk to drive gut-brain signalling.

Kouki K Touhara, Jinhao Xu, Joel Castro, Hong-Erh Liang, Guochuan Li, Mariana Brizuela, Andrea M Harrington, Sonia Garcia-Caraballo, Tracey O'Donnell, Daniel Neumann and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kouki K TouharaDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA. Koki.Tohara@ucsf.edu.ORCID http://orcid.org/0000-0003-3167-9784
Jinhao XuDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-4018-2825
Joel CastroVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Hong-Erh LiangDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Guochuan LiState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, Beijing, China.
Mariana BrizuelaVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Andrea M HarringtonVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Sonia Garcia-CaraballoVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Tracey O'DonnellVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Daniel NeumannVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Nathan D RossenDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Fei DengState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, Beijing, China.
Gudrun SchoberVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Yulong LiState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-9166-9919
Richard M LocksleyDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5468-6867
Stuart M BrierleyVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-2527-2905
David JuliusDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA. David.Julius@ucsf.edu.ORCID http://orcid.org/0000-0002-6365-4867

Funding

Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 2012 to 2023
$23.3M
Natural products as probes of the pain pathwayR35NS105038 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JULIUS, DAVID · 2018 to 2025
$9.0M
Novel fluorescent sensors for imaging neuromodulationU01NS113358 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAN, YANG, LI, YULONG · 2019 to 2022
$4.3M
Parasite immunity orchestrated by type 2 immune cellsR01AI026918 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 1988 to 2022
$3.8M
Parasite Immunity Orchestrated by Th2 CellsR37AI026918 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 2006 to 2015
$3.8M
Optimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulationU01NS120824 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2021 to 2024
$3.6M
Understanding Mechanisms and Sex-Differences in Visceral PainR01DK135714 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLY A. INGRAHAM, David Julius · 2023 to 2026
$3.4M
Mapping gut-spinal cord connections in visceral painU01NS113869 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A., JULIUS, DAVID · 2019 to 2021
$2.4M
Wide field-of-view Spinning Disk Confocal with Photoactivation and PhotobleachingS10OD017993 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THORN, KURT · 2015 to 2015
$274k
NHLBI NIH HHS P01 HL107202NIAID NIH HHS R01 AI026918NIAID NIH HHS R37 AI026918NIDDK NIH HHS R01 DK135714NIH HHS S10 OD017993NINDS NIH HHS R35 NS105038NINDS NIH HHS U01 NS113358NINDS NIH HHS U01 NS113869NINDS NIH HHS U01 NS120824
6 · The paper itself

Abstract

Parasitic infections modulate both immune and sensory responses, but how these systems collaborate to elicit protective behaviours remains incompletely understood. The gut epithelium contains specialized sensory cells that detect pathogens and irritants. These include cholinergic tuft cells, which sense parasites and initiate type 2 immune responses

Indexed as

Brain-Gut AxisEpithelial CellsIntestinal MucosaAcetylcholineAnimalsBrainEatingEnterochromaffin CellsFemaleMaleMiceMice, Inbred C57BLParacrine CommunicationReceptors, MuscarinicSerotoninSignal TransductionAcetylcholineReceptors, MuscarinicSerotonin

Identifiers

PMID41882357
PMCPMC13171452

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.