Evidence map›Paper›PMID 41882354›Full record

ArticleNature2026

Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion.

Christopher B Medina, Ewelina Sobierajska, Minghao Gong, Daniel T McManus, Maheshwor Thapa, Judong Lee, Se Jin Im, Jason E Toombs, Joshua M Mitchell, Yating Wang and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Christopher B MedinaEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Ewelina SobierajskaDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.
Minghao GongThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Daniel T McManusEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0009-0003-1307-3380
Maheshwor ThapaThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Judong LeeEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-7064-1079
Se Jin ImEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Jason E ToombsDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Joshua M MitchellThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.ORCID http://orcid.org/0000-0003-1598-1596
Yating WangThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Jennifer W CarlisleWinship Cancer Institute of Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7085-4640
Gordon J FreemanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7210-5616
Viraj A MasterDepartment of Urology, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-7251-142X
Suresh S RamalingamWinship Cancer Institute of Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-0757-3106
Haydn T KissickEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0001-7624-5598
Shuzhao LiThe Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Rolf A BrekkenDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-2704-2377
Rafi AhmedEmory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA. rahmed@emory.edu.ORCID http://orcid.org/0000-0002-9591-2621

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In cancer and chronic infection, CD8 T cell exhaustion is hallmarked by expression of inhibitory receptors such as PD1, TIM3, LAG3 and others

Indexed as

CD8-Positive T-LymphocytesPhosphatidylserinesAnimalsCell MembraneFemaleHumansLymphocyte ActivationLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMaleMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorT-Cell ExhaustionPhosphatidylserinesProgrammed Cell Death 1 Receptor

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.