Evidence map›Paper›PMID 41882353›Full record

ArticleNature2026

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity.

Sam O Kleeman, Kevin Michalski, Xiang Zhao, Ruben Steigerwald, Miriam Ferrer, Llewelyn Levett, Ethan Ertel, Austin Schultz, Noriko Simorowski, Pamela Moody and 15 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Sam O KleemanCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Kevin Michalski *Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Xiang Zhao *Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0003-3067-3970
Ruben SteigerwaldCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Miriam FerrerCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Llewelyn LevettCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Ethan ErtelCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Austin SchultzCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0009-0000-2406-8497
Noriko SimorowskiCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Pamela MoodyCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Tse-Luen WeeCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0002-4141-3157
Cristina ValenteDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, USA.
Sharon FoxDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, USA.
Mateusz MakuchDepartments of Neurology and Neurosciences, Mayo Clinic, Jacksonville, FL, USA.
Selina ThomsenDepartments of Neurology and Neurosciences, Mayo Clinic, Jacksonville, FL, USA.
Ruby HarrisonOxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2985-8652
Claire ReganCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0002-1623-4771
Jonathan PreallCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0002-7772-2437
Qing GaoCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Dennis ThomasCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0003-1691-2023
Jill HabelCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Rachel RubinoCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Sarosh IraniDepartments of Neurology and Neurosciences, Mayo Clinic, Jacksonville, FL, USA.ORCID http://orcid.org/0000-0002-7667-9748
Hiro FurukawaCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. furukawa@cshl.edu.ORCID http://orcid.org/0000-0001-8296-8426
Tobias JanowitzCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. janowitz@cshl.edu.ORCID http://orcid.org/0000-0002-7820-3727

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI LINGBO ZHANG · 1987 to 2026
$118.9M
NCI NIH HHS P30 CA045508
6 · The paper itself

Abstract

Autoimmunity and anti-cancer immunity lie on the same biological continuum

Indexed as

AutoimmunityGerm CellsReceptors, N-Methyl-D-AspartateTriple Negative Breast NeoplasmsAnimalsAntibody AffinityAutoantibodiesB-LymphocytesCryoelectron MicroscopyFemaleHumansMiceParaneoplastic Syndromes, Nervous SystemAutoantibodiesNR2B NMDA receptorReceptors, N-Methyl-D-Aspartate

Identifiers

PMID41882353
PMCPMC13216075

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.