Observational studyInfection2026
Clinical and microbial insights into polymicrobial vascular graft infections: a prospective observational study.
Observational study in Infection, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectivesVascular graft/endograft infections (VGEI) are difficult-to-treat and associated with high morbidity and mortality. Up to 40% of VGEI are polymicrobial, complicating clinical management. This study investigates microbial interactions and their impact on clinical outcomes.
methodsWe analyzed patient characteristics and survival in poly- versus monomicrobial infections from the VASGRA cohort, a Swiss prospective observational study. Kaplan-Meier analysis and Cox proportional hazards models were used to assess survival. Furthermore, a subset of patient-derived bacterial strains underwent Quantitative Fitness Analysis (QFA) to quantify changes in fitness in mono- and polymicrobial conditions.
resultsAmong 227 VGEI episodes, 81 (35.7%) were polymicrobial. Overall survival was 87.7% at one year and 77.5% at five years, with polymicrobial infections associated with reduced survival (log-rank p = 0.004). Multivariable analyses confirmed that polymicrobial infections (adjusted HR = 2.94, 95% CI: 1.60-5.41, p < 0.001) and age per 10 years older (adjusted HR = 2.07, 95% CI: 1.26-3.41, p = 0.004) were independent risk factors for increased mortality. There was also a trend of an association with diabetes mellitus (adjusted HR = 1.95, 95% CI: 0.91-4.29, p = 0.088). QFA of five strain pairs revealed diverse interaction patterns among pathogens, ranging from complete inhibition to enhanced growth in co-culture.
conclusionPolymicrobial infections, along with older age and diabetes mellitus, were identified as independent risk factors for increased mortality in VGEI patients. QFA revealed diverse bacterial interactions, highlighting the complexity of polymicrobial environments in VGEI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.