ArticleThe AAPS journal2026
Multicomponent Interactive Release (MIR) Model for Herbal Extract/Multidrug-Loaded Electrospun Nanofibers: A Mechanistic Framework Integrating Diffusion, Swelling, and Erosion.
Article in The AAPS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Modeling Bioactive Release from Cyclodextrin Complex-Loaded Polymeric Films: A Unified Theoretical Framework Integrating Host-Guest Thermodynamics, Partitioning, and Multi-Mechanism Transport.AAPS PharmSciTech · 2026Article
- A Rate-Weighted Framework for Diffusion, Swelling, and Erosion in Monolithic Polymeric Devices: Geometry-Unified Analytical Forms and a priori Mechanism Weights from Polymer-Solvent Thermodynamics.Pharmaceutical research · 2026Article
- Article
- Correction: Multicomponent Interactive Release (MIR) Model for Herbal Extract/Multidrug-Loaded Electrospun Nanofibers: A Mechanistic Framework Integrating Diffusion, Swelling, and Erosion.The AAPS journal · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controlled release of multiple herbal bioactives from electrospun polymeric fibers involves complex coupling of diffusion, polymer relaxation, swelling, and erosion within porous mat architectures. This work establishes the Multicomponent Interactive Release (MIR) model, a comprehensive framework integrating component-specific transport mechanisms with molecular interactions and mat-scale structural effects. I revisited first-principles constitutive equations for three physicochemical regimes: rigid matrices (diffusion-controlled), swollen matrices (anomalous transport), and eroding matrices (degradation-controlled). The model addresses multi-scale release from intra-fiber radial diffusion to inter-fiber transport through tortuous pore networks governed by mat porosity (ε), tortuosity (τ), fiber diameter, and packing density. Critical analysis reveals that established empirical models (Higuchi, Korsmeyer-Peppas, Peppas-Sahlin, Hopfenberg) emerge as limiting cases, with the release exponent n arising from the Deborah number. Validation against dexamethasone/PLGA and dual contraceptive drug systems demonstrates superior predictive capability (R
Indexed as
Identifiers
41882320What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.