Evidence map›Paper›PMID 41882256›Full record

ArticleMolecular psychiatry2026

Inflammation increases the penetrance of behavioral impairment in Shank3 haploinsufficiency mice - can it explain the behavioral regression in Autism?

Sheng-Nan Qiao, Sung Eun Wang, Kun-Yong Kim, Sungsin Jo, Yong-Hui Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sheng-Nan QiaoDepartment of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.ORCID http://orcid.org/0000-0002-5182-8073
Sung Eun WangDepartment of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.ORCID http://orcid.org/0000-0002-0526-588X
Kun-Yong KimDepartment of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.
Sungsin JoDepartment of Biology, Soonchunhyang University, Soonchunhyang-ro 22, Sinchang-myeon, Asan, South Korea.
Yong-Hui JiangDepartment of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. yong-hui.jiang@yale.edu.ORCID http://orcid.org/0000-0001-6188-8806

Funding

Molecular and circuitry mechanism underlying autism behaviors in Shank3 mouse modelsR01MH117289 · NIMH · YALE UNIVERSITY · PI JIANG, YONG-HUI · 2019 to 2023
$3.2M
Characterizing the (epi)genetics of oxytocin response in clinical and animal modelsR01HD088007 · NICHD · DUKE UNIVERSITY · PI GREGORY, SIMON G, JIANG, YONG-HUI · 2017 to 2021
$2.9M
Analysis of Shank3 Complete and Temporal and Spatial Specific Knockout MiceR01MH098114 · NIMH · DUKE UNIVERSITY · PI JIANG, YONG-HUI · 2012 to 2016
$2.2M
A novel neural circuit analysis paradigm to model autism in miceR21MH104316 · NIMH · DUKE UNIVERSITY · PI JIANG, YONG-HUI · 2014 to 2015
$435k
A novel paradigm to dissect the function connectivity in Shank3 autism modelR21HD087795 · NICHD · YALE UNIVERSITY · PI JIANG, YONG-HUI · 2017 to 2018
$434k
National Research Foundation of Korea (NRF) RS-2024-00401971National Research Foundation of Korea (NRF) RS-2024-00409006NICHD NIH HHS R01 HD088007NICHD NIH HHS R21 HD087795NIMH NIH HHS R01 MH098114NIMH NIH HHS R01 MH117289NIMH NIH HHS R21 MH104316U.S. Department of Health & Human Services | National Institutes of Health (NIH) HD088007, MH104316, MH098114, MH117289, HD087795
6 · The paper itself

Abstract

Behavioral regression occurs in approximately 40% of individuals with SHANK3-associated autism spectrum disorder (ASD). We previously reported that significant behavioral regression in a small cohort of patients with SHANK3 haploinsufficiency, triggered by subclinical infections, responded to immunomodulator treatments. We hypothesize that behavioral regression results from the interplay between SHANK3 deficiency and neuroinflammation. Using Shank3 exon 4-22 deletion heterozygous mutant (Sh3

Indexed as

Autistic DisorderNerve Tissue ProteinsAnimalsAnxietyAutism Spectrum DisorderBehavior, AnimalDisease Models, AnimalHaploinsufficiencyInflammationLipopolysaccharidesMaleMiceMice, Inbred C57BLMicrofilament ProteinsMicrogliaPenetranceLipopolysaccharidesMicrofilament ProteinsNerve Tissue ProteinsShank3 protein, mouse

Identifiers

PMID41882256
PMCPMC13364677

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.