Evidence map›Paper›PMID 41882186›Full record

ArticleScientific reports2026

Challenges in the standardization of in vitro cytotoxicity assays for comparative risk assessment of cold atmospheric pressure plasma devices.

Lars Boeckmann, Philipp-Kjell Ficht, Thoralf Bernhardt, Thomas Borchardt, Agnieszka Ossowska, Wieland Milz, Andreas Helmke, Sander Bekeschus, Steffen Emmert

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lars BoeckmannClinic and Policlinic for Dermatology, Venereology, and Allergology, University Medical Center Rostock, Rostock, Germany. lars.boeckmann@med.uni-rostock.de.
Philipp-Kjell FichtClinic and Policlinic for Dermatology, Venereology, and Allergology, University Medical Center Rostock, Rostock, Germany.
Thoralf BernhardtClinic and Policlinic for Dermatology, Venereology, and Allergology, University Medical Center Rostock, Rostock, Germany.
Thomas BorchardtFaculty of Engineering and Health, HAWK University of Applied Sciences and Arts Hildesheim/Holzminden/Goettingen, Goettingen, Germany.
Agnieszka OssowskaClinic and Policlinic for Dermatology, Venereology, and Allergology, University Medical Center Rostock, Rostock, Germany.
Wieland MilzClinic and Policlinic for Dermatology, Venereology, and Allergology, University Medical Center Rostock, Rostock, Germany.
Andreas HelmkeFaculty of Engineering and Health, HAWK University of Applied Sciences and Arts Hildesheim/Holzminden/Goettingen, Goettingen, Germany.
Sander BekeschusClinic and Policlinic for Dermatology, Venereology, and Allergology, University Medical Center Rostock, Rostock, Germany.
Steffen EmmertClinic and Policlinic for Dermatology, Venereology, and Allergology, University Medical Center Rostock, Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold atmospheric pressure plasma (CAP) has emerged as a promising therapeutic modality in wound healing, with multiple devices now certified for clinical use. However, the constructive and functional diversity of CAP technologies poses significant challenges for cross-device comparison in preclinical in vitro studies. In this study, we evaluated how device-specific parameters and experimental conditions influence cytotoxic outcomes across different CAP technologies. Using L929, GM00637, and HaCaT cells, we compared direct treatment with a plasma jet (kINPen

Indexed as

Plasma GasesAnimalsAtmospheric PressureCell LineCell SurvivalHumansMiceRisk AssessmentPlasma GasesCold gas plasmaCytotoxicityPlasma medicineStandardsTreatment parameters

Identifiers

PMID41882186
PMCPMC13031891

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.