Evidence map›Paper›PMID 41882123›Full record

ArticleScientific reports2026

Multimerin1 and not Galectin-8 tempers WNT signaling to promote gastric chief cell differentiation.

Xiaobo Lin, Gabriel Nicolazzi, Xuemei Liu, Chinye Nwokolo, Yehiel Zick, José B Sáenz, Jeffrey W Brown

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Xiaobo LinDivision of Gastroenterology, Department of Medicine, School of Medicine, Washington University in St. Louis, 660 S. Euclid Avenue, Campus Box 8124, St. Louis, MO, 63110, USA.
Gabriel NicolazziDivision of Gastroenterology, Department of Medicine, School of Medicine, Washington University in St. Louis, 660 S. Euclid Avenue, Campus Box 8124, St. Louis, MO, 63110, USA.
Xuemei LiuDivision of Gastroenterology, Department of Medicine, School of Medicine, Washington University in St. Louis, 660 S. Euclid Avenue, Campus Box 8124, St. Louis, MO, 63110, USA.
Chinye NwokoloDivision of Gastroenterology, Department of Medicine, School of Medicine, Washington University in St. Louis, 660 S. Euclid Avenue, Campus Box 8124, St. Louis, MO, 63110, USA.
Yehiel ZickDepartment of Molecular Cell Biology, Weizmann Institute of Science, 76100, Rehovot, Israel.
José B SáenzDivision of Gastroenterology, Department of Medicine, School of Medicine, Washington University in St. Louis, 660 S. Euclid Avenue, Campus Box 8124, St. Louis, MO, 63110, USA.
Jeffrey W BrownDivision of Gastroenterology, Department of Medicine, School of Medicine, Washington University in St. Louis, 660 S. Euclid Avenue, Campus Box 8124, St. Louis, MO, 63110, USA. brownjw@wustl.edu.

Funding

The double-stranded RNA (dsRNA) response in gastric pre-neoplasiaR01DK141682 · NIDDK · WASHINGTON UNIVERSITY · PI Jose Bernardo Saenz · 2025 to 2026
$1.1M
Neoglycosylation Epitopes in Metaplasia and CancerK08DK132496 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2022 to 2026
$827k
Exploiting the Salivary Arsenal to Inhibit Diarrheal DiseaseR21AI156236 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BULLITT, ESTHER · 2021 to 2022
$466k
Congressionally Directed Medical Research Programs W81XWH-20-1-0630Foundation for Barnes-Jewish Hospital PREVENTIsraeli Science Foundation 776/13NIAID NIH HHS R21 AI156236NIDDK NIH HHS DK132496NIDDK NIH HHS K08 DK132496NIDDK NIH HHS R01 DK141682Samuil and Petr Polsky Cancer Research Fund 7218400101The Minerva Foundation 711425
6 · The paper itself

Abstract

Galectins are a family of proteins that bind galactose-containing glycans. One member, galectin-8, preferentially binds galactose that contains a terminal sulfate. Aberrant expression and secretion of sulfated glycosylation epitopes, such as 3'-Sulfo-Le

Indexed as

Cell DifferentiationChief Cells, GastricGalectinsWnt Signaling PathwayAnimalsGastric MucosaHumansMiceMice, Knockoutgalectin-8, mouseGalectinsCancerGastric maturationMetaplasiaStomach

Identifiers

PMID41882123
PMCPMC13171876

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.