ArticleScientific reports2026
A cross-sectional study on dysphagia-related quality of life and its associated factors in chinese patients with sjögren's syndrome.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dysphagia is a recognized complication of Sjögren’s syndrome (SS) that can affect quality of life. In this cross-sectional study, we evaluated dysphagia-related quality of life and its associated factors in Chinese patients with SS. A total of 231 patients diagnosed with SS were enrolled. Dysphagia-related quality of life was assessed using the MD Anderson Dysphagia Inventory (MDADI), with a cutoff score of < 60 defining impaired dysphagia-related quality of life as a patient-reported outcome measure. Additional assessments included the Fatigue Severity Scale (FSS), Visual Analog Scale (VAS) for pain, Oral Health Impact Profile-14 (OHIP-14), Pittsburgh Sleep Quality Index (PSQI), and Hospital Anxiety and Depression Scale (HADS). Laboratory analyses included C-reactive protein and erythrocyte sedimentation rate (ESR). The mean total MDADI score was 71.46 ± 17.83, and 22.9% of patients reported impaired dysphagia-related quality of life (MDADI < 60). In multivariable analysis, the following factors were significantly associated with impaired dysphagia-related quality of life: poorer oral health (OR: 1.073; 95% CI: 1.033–1.114; p < 0.001), higher anxiety levels (OR: 1.245; 95% CI: 1.113–1.393; p < 0.001), greater fatigue severity (OR: 1.033; 95% CI: 1.002–1.065; p = 0.036), and elevated ESR (OR: 1.020; 95% CI: 1.003–1.038; p = 0.018). Impaired dysphagia-related quality of life was reported by 22.9% of Chinese patients with SS in this sample. The factors identified as independently associated with this outcome—including poorer oral health, elevated ESR, greater fatigue, and higher anxiety levels—may inform clinical awareness and guide future research.
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