Evidence map›Paper›PMID 41882074›Full record

ArticleScientific reports2026

Heat shock factor-1 alleviates ER-stress in Caenorhabditis elegans.

Saqib Ahmed, Dániel Kovács, Márton Kovács, Mónika Kosztelnik, Bernadette Hotzi, Tímea Sigmond, Éva Saskői, Viktor Vázsony Vincze, Viktor Erdélyi, Veronika Deák and 3 more

Erratum issuedAbstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Nutrients · 2026
    Article
  2. More than the 'master regulator of cytosolic proteostasis': new roles for HSF1 in promoting tissue health.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Saqib Ahmed *Department of Genetics, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.
Dániel Kovács *Department of Genetics, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.
Márton KovácsDepartment of Genetics, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.
Mónika KosztelnikDepartment of Genetics, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.
Bernadette HotziDepartment of Genetics, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.
Tímea SigmondDepartment of Genetics, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.
Éva SaskőiDepartment of Genetics, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.
Viktor Vázsony VinczeDepartment of Genetics, Institute of Biology, Eötvös Loránd University, Budapest, Hungary.
Viktor ErdélyiDepartment of Applied Biotechnology and Food Science, Laboratory of Biochemistry and Molecular Biology, University of Technology, Budapest, Hungary.
Veronika DeákDepartment of Applied Biotechnology and Food Science, Laboratory of Biochemistry and Molecular Biology, University of Technology, Budapest, Hungary.
Ibolya StillerDepartment of Molecular Biology, Institute of Biochemistry and Molecular Biology, Semmelweis University, Budapest, Hungary.
Tibor VellaiDepartment of Genetics, Institute of Biology, Eötvös Loránd University, Budapest, Hungary. vellai.tibor@ttk.elte.hu.ORCID http://orcid.org/0000-0002-3520-2572
János BarnaDepartment of Genetics, Institute of Biology, Eötvös Loránd University, Budapest, Hungary. barna.janos@ttk.elte.hu.ORCID http://orcid.org/0000-0002-9242-0939

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Cells can be exposed to many different stimuli that induce a variety of stresses, such as oxidative stress and proteotoxic stress of the cytoplasm, endoplasmic reticulum or mitochondria. These types of stresses trigger conserved molecular pathways (e.g., heat shock response, unfolded protein response, and autophagy) that can restore cellular homeostasis. Dysfunction (deficiency or hyperactivity) of these pathways is associated with aging and pathologies such as neurodegenerative diseases, diabetes and cancer. The basic molecular machinery of these stress response pathways has been elucidated, but how these pathways interact remains a vibrant area of research. Here, we show that the heat shock transcription factor-1 (HSF-1), the master regulator of the heat shock response, is required for efficient activation of the endoplasmic reticulum unfolded protein response (UPR

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsEndoplasmic Reticulum StressTranscription FactorsAnimalsDNA-Binding ProteinsEndoplasmic ReticulumHeat-Shock ResponseHeat Shock Transcription FactorsHumansProteotoxic StressTunicamycinUnfolded Protein ResponseCaenorhabditis elegans ProteinsDNA-Binding Proteinsheat shock factor-1, C elegansHeat Shock Transcription FactorsTranscription FactorsTunicamycinCaenorhabditis elegansEndoplasmic reticulumHeat shock factorProteotoxic stressUnfolded protein response

Identifiers

PMID41882074
PMCPMC13018630

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.