Evidence map›Paper›PMID 41882068›Full record

ArticleScientific reports2026

Final adult height in Korean children with idiopathic growth hormone deficiency after growth hormone treatment.

Min Hyung Cho, Se Jin An, Young Suk Shim, Jin Soon Hwang, Hae Sang Lee

Abstract read
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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Min Hyung ChoDepartment of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, Korea.
Se Jin AnDepartment of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, Korea.
Young Suk ShimDepartment of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, Korea.
Jin Soon HwangDepartment of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, Korea.
Hae Sang LeeDepartment of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, San 5, Wonchon-dong, Yeongtong-gu, Suwon, 443-721, Korea. seaon98@ajou.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated final adult height (FAH) outcomes and associated predictive factors in patients with idiopathic growth hormone deficiency (IGHD) treated with recombinant human growth hormone (GH). We retrospectively analyzed medical records of prepubertal patients who initiated GH treatment from August 2003. As of July 2024, FAH data were available for 60 patients (40 males, 20 females). The patients started GH therapy at a mean age of 8.5 years and were treated for an average of 6.5 years. Mean height improved from - 2.6 to - 1.1 standard deviation score (SDS) following treatment. GH treatment was initiated at a significantly younger age in females. Mean FAH was 168.5 ± 4.4 cm (- 1.1 ± 0.8 SDS) in males and 156.0 ± 3.3 cm (- 1.1 ± 0.7 SDS) in females. FAH SDS was comparable to target height SDS. Multiple regression analysis showed that FAH SDS was positively associated with initial height SDS (B = 0.72, 95% CI 0.270-1.182) and negatively associated with baseline insulin-like growth factor-1 (IGF-1) SDS (B = - 0.347, 95% CI - 0.501 to - 0.192) (Adjusted R

Indexed as

Body HeightDwarfism, PituitaryHuman Growth HormoneChildChild, PreschoolFemaleHumansInsulin-Like Growth Factor IMaleRecombinant ProteinsRepublic of KoreaRetrospective StudiesTreatment OutcomeHuman Growth HormoneInsulin-Like Growth Factor IRecombinant ProteinsFinal adult heightGrowth hormoneIdiopathic growth hormone deficiency

Identifiers

PMID41882068
PMCPMC13172338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.