Evidence map›Paper›PMID 41882059›Full record

ArticleScientific reports2026

Large language models versus human examinee performance on Israeli anesthesiology board examinations.

Ariel Ronen, Shai Fein, Sharon Orbach-Zinger, Philip Heesen, Omer Shpack, Adham Kashkush, Daniel Iluz-Freundlich, Yair Binyamin, Mirit Lahav, Nadav Sheffy and 1 more

Abstract readComparative Study
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ariel RonenDepartment of Anesthesiology, Hadassah Hebrew University Medical Center Mt. Scopus, Jerusalem, Israel. arielro@hadassah.org.il.
Shai FeinDepartment of Anesthesiology, Beilinson Hospital, Rabin Medical Center and the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Sharon Orbach-ZingerDepartment of Anesthesiology, Beilinson Hospital, Rabin Medical Center and the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Philip HeesenDepartment of Mathematics and Statistics, University of Strathclyde, Glasgow, Scotland.
Omer ShpackDepartment of Anesthesiology, Beilinson Hospital, Rabin Medical Center and the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Adham KashkushDepartment of Anesthesiology, Beilinson Hospital, Rabin Medical Center and the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Daniel Iluz-FreundlichDepartment of Anesthesiology, Beilinson Hospital, Rabin Medical Center and the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Yair BinyaminDepartment of Anesthesiology, Soroka University Medical Center, and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Mirit LahavDepartment of Anesthesiology, Critical Care and Pain Management, Meir Medical Center and the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Nadav SheffyDepartment of Anesthesiology, Beilinson Hospital, Rabin Medical Center and the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Karam AzemDepartment of Anesthesiology, Beilinson Hospital, Rabin Medical Center and the Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large Language Models (LLMs) demonstrate increasing capabilities in medical knowledge assessment, yet limitations remain in cross-population validation, direct human-AI comparisons, and evaluation of newer models in anesthesiology contexts. This study addresses these gaps by conducting a head-to-head comparison between newer LLMs and human examinees on official Israeli multiple-choice board examinations. We evaluated two LLMs (Claude 3.7 Sonnet and ChatGPT-4) against anonymized aggregate data from 381 examinees on three consecutive official Israeli anesthesiology board examinations (2023–2024), comprising 450 multiple-choice questions stratified by difficulty, discrimination ability, and topic. Each model was tested twice per exam. Claude 3.7 Sonnet achieved 73.67% accuracy, significantly outperforming both human examinees (62.77%, P < 0.001) and ChatGPT-4 (64.44%, P < 0.001). However, both LLMs performed below the upper quartile of human performance (78.05%). While LLMs excelled on easy questions and theoretical domains like cardiac physiology (Claude: 96.88%, ChatGPT-4: 81.25%), they showed lower performance in areas such as ambulatory (Claude: 30.00%, ChatGPT-4: 10.00%) and regional anesthesia (Claude: 44.44%, ChatGPT-4: 38.89%). Human examinees demonstrated consistent performance across all domains, whereas LLMs showed extreme variability. Self-consistency was substantial for both LLMs (κ = 0.66–0.68), but agreement with human responses was moderate (κ = 0.34–0.39). While advanced LLMs currently exceed average examinee performance on anesthesiology board examinations, they fall short of top-quartile examinees at present and demonstrate significant performance variability across different topic areas.

Indexed as

AnesthesiologyEducational MeasurementLarge Language ModelsGenerative Artificial IntelligenceHumansIsraelAnesthesiologyArtificial intelligenceClinical competenceEducationMedical

Identifiers

PMID41882059
PMCPMC13171908

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.