ReviewDifferentiation; research in biological diversity
Roles of the RNA-binding protein SRSF3 in development and cellular differentiation.
Review in Differentiation; research in biological diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Disease-driven post-transcriptional alterations and alternative splicing in podocytes in focal segmental glomerulosclerosis.EMBO molecular medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
RNA-binding proteins have been established as essential regulators of embryonic development, cellular differentiation and tissue homeostasis. In this review, we highlight the roles of the highly conserved serine/arginine-rich (SR) family member SRSF3 during these processes across a range of organisms. We summarize information regarding the structure and post-translational regulation of SRSF3. Next, we provide an overview of demonstrated roles of SRSF3 in multiple steps of RNA metabolism, including alternative RNA splicing, transcription termination, polyadenylation, stability, transcript nuclear export and miRNA biogenesis. We then discuss the involvement of SRSF3 in various intracellular signaling cascades, including those of the PDGF, EGF, insulin, JAK/STAT, mTOR, retinoic acid, TGF-β and canonical Wnt signaling pathways. Finally, we highlight expression patterns of SRSF3 during embryogenesis and the functions of SRSF3 in the context of mouse germ cell, early embryo, craniofacial, heart and B cell development, as well as in hepatocyte, megakaryocyte and macrophage maturation. We conclude with critical unanswered questions and future directions that should provide significant insight into the roles of SRSF3 in gene expression regulation during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.