Evidence map›Paper›PMID 41881966›Full record

ArticleCell death discovery2026

RUNX1 restrains STAT1-GITRL signaling to shape an immunosuppressive CRC microenvironment.

Wenting He, Lisheng Zheng, Weiye Huang, Keren Li, Yitian Chen, Rui Zeng, Zhihao Lin, Yangwei Xu, Shengfeng Hu, Qingling Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenting He *Guangdong Cardiovascular Institute, Guangzhou, China.ORCID http://orcid.org/0000-0002-8817-9572
Lisheng Zheng *Department of Pathology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Weiye Huang *Department of Pathology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Keren Li *Hepatopancereatobiliary Center, Tsinghua University Affiliated Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Yitian ChenThe Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, China.
Rui ZengDepartment of Pathology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhihao LinDepartment of Pathology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yangwei XuDepartment of Pathology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.ORCID http://orcid.org/0000-0003-4534-2031
Shengfeng HuThe Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, China. hushengfeng@gzhmu.edu.cn.ORCID http://orcid.org/0000-0001-7901-4410
Qingling ZhangDepartment of Pathology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. zhangqingling@gdph.org.cn.ORCID http://orcid.org/0000-0002-5287-264X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82402997
6 · The paper itself

Abstract

The oncogenic role of RUNX1 in epithelial tumors is increasingly recognized, however, its function and mechanism within the tumor immune microenvironment (TME) of colorectal cancer (CRC) remain unclear. This study investigates the contribution of RUNX1 to TME remodeling in CRC. Analysis of clinical CRC tissues revealed that RUNX1 expression is negatively correlated with GITRL levels in tumor cells and is associated with increased infiltration of Treg cells. Functional studies demonstrated that RUNX1 impairs GITRL-GITR signaling, thereby promoting Treg cell infiltration while suppressing CD8

Identifiers

PMID41881966
PMCPMC13040063

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.