ArticleAddiction biology2026
Expression and Clinical Significance of the Long Non-Coding RNA OIP5-AS1 in Alcohol Use Disorder.
Article in Addiction biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The present study aimed to investigate the expression of OIP5-AS1 in alcohol use disorder and to explore its potential clinical relevance. A total of 78 patients with alcohol use disorder and 36 healthy controls were enrolled in this study. Clinical data were collected for all participants. The expression levels of OIP5-AS1 were quantified using quantitative real-time polymerase chain reaction (RT-PCR). Receiver operating characteristic (ROC) analysis was subsequently performed to evaluate the diagnostic value of OIP5-AS1. StarBase-based bioinformatics analysis suggested that OIP5-AS1 may function within a miRNA-mediated regulatory network influencing SERPINA3 expression. OIP5-AS1 expression levels, as determined by RT-PCR, were markedly higher in patients with alcohol use disorder than in healthy controls (p < 0.001). Patients were stratified into high- and low-expression groups based on the median OIP5-AS1 level. Comparative analyses of baseline characteristics and clinical parameters showed that body mass index (BMI) was significantly lower in the high-expression group, and this inverse association between OIP5-AS1 expression and BMI remained statistically significant in subsequent logistic regression analyses. ROC analysis demonstrated that OIP5-AS1 had strong diagnostic performance, yielding an area under the curve of 0.9091 (p < 0.0001), with a sensitivity of 100% and a specificity of 75% at the defined cutoff. In conclusion, OIP5-AS1 expression was significantly increased in patients with alcohol use disorder and was inversely associated with BMI. In addition, OIP5-AS1 demonstrated good diagnostic performance in distinguishing patients with alcohol use disorder from healthy controls. These findings suggest that OIP5-AS1 may have potential clinical relevance in alcohol use disorder and merit further investigation.
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