Evidence map›Paper›PMID 41881640›Full record

ArticleBritish journal of anaesthesia2026

Perioperative neurocognitive disorders: the importance of global systemic interactions.

Diany P Calderon, Hugh C Hemmings

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of anaesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Diany P CalderonDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. Electronic address: dpc2003@med.cornell.edu.
Hugh C HemmingsDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.

Funding

SYNAPTIC MECHANISMS OF GENERAL ANESTHETIC ACTIONR01GM058055 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HEMMINGS, HUGH C · 1998 to 2023
$10.1M
Mechanisms and Functions of Cortical Activity to Restore BehaviorR01NS129836 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Diany Paola Calderon · 2023 to 2026
$2.1M
NIGMS NIH HHS R01 GM058055NINDS NIH HHS R01 NS129836
6 · The paper itself

Abstract

Perioperative neurocognitive disorders (PNDs) are a spectrum of cognitive impairments that can occur after anaesthesia and surgery, most often in older adults. They are linked to worse outcomes and higher mortality. Despite several proposed mechanisms, effective prevention and treatment remain limited, suggesting that key triggers of PNDs remain unknown or that our understanding of PND pathophysiology is incomplete. The review article by Ba and colleagues highlights the role of extrasynaptic γ-aminobutyric acid type A (GABA

Indexed as

Neurocognitive DisordersPostoperative Cognitive ComplicationsAnesthesiaHumansReceptors, GABA-ARisk FactorsReceptors, GABA-Aageingextrasynaptic GABA(A) receptorsperioperative neurocognitive disordersα5 subunitδ subunit

Identifiers

PMID41881640
PMCPMC13198184

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.