Evidence map›Paper›PMID 41881566›Full record

ArticleMedical physics2026

Kinetic model of radiochemical oxygen depletion (ROD) in FLASH radiotherapy.

Joao Seco, Hugo Freitas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joao SecoDivision of Biomedical Physics in Radiation Oncology, DKFZ, German Cancer Research Centre, Heidelberg, Germany.
Hugo FreitasDivision of Biomedical Physics in Radiation Oncology, DKFZ, German Cancer Research Centre, Heidelberg, Germany.

Funding

Deutsche Krebshilfe Grant, Entitled "Dosisleistungsabhangige Ande-rung des Sauerstoffpartlaldrucks wahrend FLASH-Bestrahlung und deren Einfluss auf die strahlenbi-ologische Wirkung in Zebrafisch Embryonen" 70115332Deutsche Krebshilfe Grant, Entitled "Dosisleistungsabhangige Ande-rung des Sauerstoffpartlaldrucks wahrend FLASH-Bestrahlung und deren Einfluss auf die strahlenbi-ologische Wirkung in Zebrafisch Embryonen" 70115445DFG Grant, Entitled "gROS - Monte Carlo GPU modelling of reactive oxygen species (ROS) during FLASH radiotherapy" 550953943DFG Grant, Entitled "PromptFLASH: Real-time in-vivo FLASH dosimetry for ion beams with prompt gamma X-ray spectroscopy" 528201597
6 · The paper itself

Abstract

backgroundThe role of oxygen in "Ultra-High Dose Rate" (UHDR) radiotherapy is currently subject to active debate, due to its importance in the FLASH effect. Radiochemical oxygen depletion (ROD) is used to characterize the removal of oxygen by its interaction with the free radicals produced by the radiation. Currently, there is a need to understand why ROD depends on the radiation dose rate and the initial oxygen pressure. PURPOSE: Development of a kinetic model of ROD that explains its dependence on (i) radiation dose rate and (ii) initial oxygen pressure,

methodsThe current work uses a variety of published ROD studies performed in vitro and in vivo in mice to evaluate the kinetic model prediction of ROD. The in vitro studies include evaluation of ROD in water, bovine serum albumin (BSA), and CELL medium consisting of HEPES (

resultsThe kinetic model

conclusionsA systematic review of all published ROD studies was performed and used as the basis for testing the novel kinetic model for ROD. The kinetic model prediction of ROD showed that the radiolysis products,

Indexed as

Models, BiologicalOxygenRadiotherapyAnimalsFemaleKineticsMaleMiceMice, Inbred C57BLOxygenFLASHoxygen consumptionradiochemical oxygen depletionROD

Identifiers

PMID41881566
PMCPMC13017082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.