Evidence map›Paper›PMID 41881555›Full record

ArticleHead & neck2026

Early-Stage Glottic Squamous Cell Carcinoma: A Nationwide Analysis on Incidence, Survival, Recurrences, and Laryngectomies After Radiotherapy in the Netherlands (2015-2021).

Sabine M L Linden, Boukje A C van Dijk, Marielle E P Philippens, Gerben E Breimer, Remco de Bree, Johannes A Rijken, Mischa de Ridder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sabine M L LindenDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-5130-3760
Boukje A C van DijkDepartment of Epidemiology, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0000-0001-5984-4716
Marielle E P PhilippensDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0003-0205-3459
Gerben E BreimerDepartment of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0003-0365-3667
Remco de BreeDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0001-7128-5814
Johannes A RijkenDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.
Mischa de RidderDepartment of Radiotherapy, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0002-2530-3038

Funding

Universitair Medisch Centrum Utrecht
6 · The paper itself

Abstract

objectiveGrowing interest in new radiotherapy strategies for early-stage glottic cancer highlights the importance of reviewing current treatment outcomes. This nationwide study presents the incidence, survival, recurrences, and laryngectomies for these patients.

methodsPatients diagnosed with cT1-2N0M0 glottic squamous cell carcinoma (SCC) between 2015 and 2021 in the Netherlands were included. Patients diagnosed between 2015 and 2019 were analyzed for survival, recurrences, and laryngectomies after radiotherapy treatment.

resultsA total of 2214 patients were diagnosed with early-stage glottic SCC. A total of 826 patients were treated with radiotherapy between 2015 and 2019. The 5-year overall survival, relative survival, and recurrence-free survival after radiotherapy were 75%, 88%, and 86%, respectively. Of the 826 patients, 47 (6%) underwent laryngectomy. Only four (0.5%) patients had a laryngectomy due to severe radiation toxicity.

conclusionThis nationwide study demonstrates that radiotherapy for early-stage glottic SCC results in excellent oncological outcomes. Radiation-induced laryngectomies for this treatment are extremely rare.

Indexed as

Carcinoma, Squamous CellGlottisLaryngeal NeoplasmsLaryngectomyNeoplasm Recurrence, LocalSquamous Cell Carcinoma of Head and NeckAgedAged, 80 and overFemaleHumansIncidenceMaleMiddle AgedNeoplasm StagingNetherlandsRetrospective Studiesearly‐stage glottic cancerhead and neck cancerlaryngectomiesoncological outcomeradiotherapy

Identifiers

PMID41881555
PMCPMC13332543

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.