Evidence map›Paper›PMID 41881531›Full record

ArticleBMJ open2026

The impact of community-based participatory health systems interventions on prevention of mother-to-child transmission of HIV (PMTCT) in sub-Saharan Africa: a systematic review and meta-analysis protocol.

Samuel Amon, Sylvester Amankwah, Janet Awopole Yepakeh Tiah, Yves Jacket Nsavyimana, Caesar Agula

Abstract read
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samuel AmonRegional Institute for Population Studies (RIPS), University of Ghana, Legon, Ghana samamonzygote@gmail.com.ORCID http://orcid.org/0000-0003-3937-175X
Sylvester AmankwahEjisu Municipal Health Directorate, Ghana Health Service, Accra, Ghana.
Janet Awopole Yepakeh TiahRegional Institute for Population Studies (RIPS), University of Ghana, Legon, Ghana.
Yves Jacket NsavyimanaCentre for Health Policy Analysis and Research, Bujumbura, Burundi.
Caesar AgulaRegional Institute for Population Studies (RIPS), University of Ghana, Legon, Ghana.ORCID http://orcid.org/0000-0001-9022-7433

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite global efforts to prevent mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV), important gaps remain, particularly in low-resource countries. Community-based health systems strengthening (HSS) interventions are emerging as a strategy towards effective prevention of mother-to-child transmission (PMTCT) of HIV services. However, the nexus between interventions and impact indicators remains unclear. This systematic review aims to assess all available evidence on the impact of community-driven HSS interventions on PMTCT. METHODS AND ANALYSIS: We will develop a search of studies published between 2015 and 2025 from databases such as PubMed/Medline, Scopus, Web of Science, Google Scholar and African Journals. We will use a combination of search terms such as 'participatory action research', 'health systems strengthening', 'PMTCT of HIV', 'childhood HIV', 'MTCT of HIV' and 'under-five mortality'. Studies aimed at community-based participatory health system intervention on PMTCT of HIV published in English will be used. Experimental, quasi-experimental and observational (including cohort and case-control) studies will be included. Data will be analysed using narrative and meta-analysis approaches. The risk of bias will be assessed using Cochrane Handbook guidelines. The primary outcome measure will cover PMTCT of HIV and secondary outcome measures are HIV prevalence and under-five mortality. Finally, the quality of evidence will be assessed using Grades of Recommendation, Assessment, Development and Evaluation technique. ETHICS AND DISSEMINATION: As no original data will be collected, ethical approval is not applicable for this study. The results will be disseminated through peer-reviewed publication and presentations at health summits and conferences. The review would inform context-sensitive HIV policies and interventions in developing countries, particularly for women and children. PROSPERO REGISTRATION NUMBER: CRD420251131511.

Indexed as

Community Health ServicesHIV InfectionsInfectious Disease Transmission, VerticalPregnancy Complications, InfectiousAfrica South of the SaharaCommunity-Based Participatory ResearchFemaleHumansMeta-Analysis as TopicPregnancyResearch DesignSystematic Reviews as TopicChildHealth & safetyHealth ServicesHIV & AIDSInfection control

Identifiers

PMID41881531
PMCPMC13034280

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.