Evidence map›Paper›PMID 41881452›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2026

Targeting the epithelium in pulmonary fibrosis.

Muriel Lizé, Christoph H Mayr, Marina Bleck, Lutz Wollin, Christian T Wohnhaas, Irina Shalashova, Heiko Olbrich, Ralf Heilker, Anna Engler, Marie-Therese Bammert and 12 more

Abstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Integrated Bioinformatics and Experimental Validation to Identify Shared Sialylation-Related Signatures in Emphysematous and Fibrotic Lung Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Murine models of pulmonary fibrosis: mechanisms, limitations and translational insights.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Muriel LizéBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Christoph H MayrBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Marina BleckBoehringer Ingelheim Pharmaceuticals Inc., Immunology and Respiratory Diseases Research, Ridgefield, CT, USA.
Lutz WollinBoehringer Ingelheim Pharma GmbH and Co. KG, Department Translational Medicine Clinical Pharmacology, Biberach an der Riß, Germany.
Christian T WohnhaasBoehringer Ingelheim Pharma GmbH and Co. KG, Department Translational Medicine Clinical Pharmacology, Biberach an der Riß, Germany.
Irina ShalashovaBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Heiko OlbrichBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Ralf HeilkerBoehringer Ingelheim Pharma GmbH and Co. KG, Department of Drug Discovery Sciences, Biberach an der Riß, Germany.
Anna EnglerBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Marie-Therese BammertBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Holger SchlüterBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Kerstin Geillinger-KästleBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Devona SoetopoBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Stephan KleeBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Felix WolfBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Jason J GokeyDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Heiko StahlBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany.
Alexander C KlimowiczBoehringer Ingelheim Pharmaceuticals Inc., Immunology and Respiratory Diseases Research, Ridgefield, CT, USA.
A Scott McCallDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-1944-220X
Jonathan A KropskiDivision of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Timothy S BlackwellDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Matthew J ThomasBoehringer Ingelheim Pharma GmbH and Co. KG, Immunology and Respiratory Disease Research, Biberach an der Riß, Germany matthew_james.thomas@boehringer-ingelheim.com.

Funding

Mechanisms of Familial Pulmonary FibrosisP01HL092870 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLACKWELL, TIMOTHY S. · 2010 to 2020
$21.6M
Project 4: Defining the Molecular Natural History of Early and Progressive Pulmonary FibrosisP01HL172729 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Timothy S. Blackwell · 2024 to 2026
$11.2M
Targeting dysfunctional epithelial repair in pulmonary fibrosisR01HL175555 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Timothy S. Blackwell · 2024 to 2026
$1.9M
BLRD VA I01 BX002378NHLBI NIH HHS P01 HL092870NHLBI NIH HHS P01 HL172729NHLBI NIH HHS R01 HL175555
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is characterised by progressive scarring primarily of the distal regions of the lung in a distinctive histological pattern. Consequently, drug discovery has focused on the activity of scar-forming fibroblasts, with some success shown by the pharmaceutical agents nintedanib and pirfenidone, and more recently nerandomilast. Yet an unmet medical need remains, pointing toward pathobiology not addressed by standard-of-care therapies. In recent years, single-cell sequencing of patient lung tissue has revealed several novel disease-associated epithelial populations. In addition, we are now beginning to understand, through functional co-culture studies, the importance of cellular crosstalk in both lung homeostasis and disease. Here, we review the advances made in "omic" technologies, the approaching spatial profiling revolution, current and future functional cell systems, novel

Indexed as

Antifibrotic AgentsEpithelial CellsIdiopathic Pulmonary FibrosisLungAnimalsHumansMolecular Targeted TherapyPhenotypeSignal TransductionAntifibrotic Agents

Identifiers

PMID41881452
PMCPMC13014285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.