Evidence map›Paper›PMID 41881181›Full record

ReviewNeuroscience and biobehavioral reviews2026

The role of GABA

Rajasekar Nagarajan, Jinrui Lyu, Jonique Catherine George, Uwe Rudolph, Elif Engin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Assessment of GABANeuroscience letters · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rajasekar NagarajanDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL, United States. Electronic address: raja786@illinois.edu.
Jinrui LyuDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL, United States; Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL, United States. Electronic address: jinruil2@illinois.edu.
Jonique Catherine GeorgeStress Neurobiology Laboratory, Division of Basic Neuroscience, McLean Hospital, Belmont, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States. Electronic address: jcgeorge@bu.edu.
Uwe RudolphDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL, United States; Neuroscience Program, University of Illinois Urbana-Champaign, Urbana, IL, United States; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, United States. Electronic address: urudolph@illinois.edu.
Elif EnginStress Neurobiology Laboratory, Division of Basic Neuroscience, McLean Hospital, Belmont, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States. Electronic address: eengin@mclean.harvard.edu.

Funding

Disruptions in the brain reward system through postnatal exposure to GABA agonists and anestheticsR01HD104656 · NICHD · MCLEAN HOSPITAL · PI ENGIN, ELIF · 2022 to 2025
$1.8M
Cellular mechanisms for age-related cognitive dysfunction and its pharmacological reversal: a strategy towards prevention and treatment of postoperative cognitive deficits in elderly patientsR01GM128183 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RUDOLPH, UWE · 2019 to 2022
$1.6M
Postoperative Neurocognitive Disorder - Strategies for Prevention or Reversal Based on Molecular ad Cellular MechanismsR35GM153232 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Uwe Rudolph · 2024 to 2026
$1.3M
NICHD NIH HHS R01 HD104656NIGMS NIH HHS R01 GM128183NIGMS NIH HHS R35 GM153232
6 · The paper itself

Abstract

The hippocampus is a central structure for learning and memory, integrating excitatory and inhibitory activity to support cognitive processing. Among inhibitory mechanisms, phasic and tonic inhibition via γ-aminobutyric acid type A receptors (GABA

Indexed as

CognitionHippocampusMemoryReceptors, GABA-AAnimalsHumansNeuronal PlasticityReceptors, GABA-ACognitive functionGABA(A) receptor subtypesHippocampusInhibitory plasticityLearning and memoryTonic inhibitionα5GABA(A) receptor

Identifiers

PMID41881181
PMCPMC13519240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.