Evidence map›Paper›PMID 41881035›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Sertoli Cell-Derived Extracellular Vesicles Orchestrate Cadmium-Induced Testicular Inflammation and Fibrosis.

Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jianfeng MaFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0003-2731-5355
Mailin GanFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Shuang LiangFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Siyu ChenFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Ziling HaoFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Yiting YangFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Jiawei LuFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Qihang WuFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Yuqian ShiFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Lijun SunFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Jiaxin LiFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Saihao WangFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Yan WangFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Xiaofeng ZhouFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Lei ChenFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Ye ZhaoFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Li ZhuFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.
Linyuan ShenFarm Animal Germplasm Resources and Biotech Breeding Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.ORCID https://orcid.org/0000-0001-6072-3268

Funding

China Agriculture Research System CARS-35National Key R&D Program of China 2024YFF1000201Pig Industry Technology System Innovation Team of Sichuan Province SCCXTD-2025-8Sichuan Science and Technology Program 2021YFYZ0030Sichuan Science and Technology Program 2021ZDZX0008Sichuan Science and Technology Program 2024NSFSC1176
6 · The paper itself

Abstract

Cadmium (Cd) is a widespread environmental toxicant that impairs male reproductive health, though its testicular toxicity mechanisms remain incompletely defined. Combining single-cell RNA sequencing with functional assays, we identified a novel intercellular communication pathway mediated by Sertoli cell-derived extracellular vesicles (EVs) in Cd-induced testicular injury. In mice, Cd exposure caused testicular atrophy, spermatogenesis disruption, and fibrosis. Multi-omics analyses revealed activation of multiple programmed cell death pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis. Single-cell RNA sequencing (scRNA-seq) demonstrated testicular cellular remodeling featuring Sertoli cell depletion and fibroblast expansion. Mechanistically, Cd triggered multi-modal programmed cell death (PCD) in Sertoli cells, promoting EV release enriched with damage-associated molecular patterns (DAMPs) and mitochondrial components. These EVs were internalized by testicular macrophages, activating the TLR4/NF-κB pathway and inducing a pro-inflammatory phenotype. Consequently, activated macrophages stimulated fibroblast-mediated fibrosis via TGF-β/Smad signaling. These findings elucidate a Sertoli cell-EV-macrophage-fibroblast axis in Cd-induced testicular damage, offering new insights into environmental toxicant-induced male infertility and potential therapeutic targets.

Indexed as

CadmiumExtracellular VesiclesFibrosisInflammationSertoli CellsTestisAnimalsApoptosisMaleMiceSignal TransductionCadmiumcadmiumextracellular vesiclesprogrammed cell deathtesticular fibrosis

Identifiers

PMID41881035
PMCPMC13248802

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.