Evidence map›Paper›PMID 41881027›Full record

ArticleAmerican journal of human genetics2026

Adaptive admixture at ACKR1, the Duffy blood group locus, may have shaped Plasmodium vivax prevalence in Oman.

Paige E Haffener, Arwa Z Al-Riyami, Shoaib Al-Zadjali, George B J Busby, Sulaiman Al-Mahdhuri, Mohammed Al-Rawahi, Saif Al-Hosni, Ali Al-Marhoobi, Ammar Al-Sheriyani, Ellen M Leffler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Paige E HaffenerDepartment of Human Genetics, the University of Utah School of Medicine, Salt Lake City, UT, USA.
Arwa Z Al-RiyamiDepartment of Hematology, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman; Department of Hematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman. Electronic address: arwa@squ.edu.om.
Shoaib Al-ZadjaliSultan Qaboos Comprehensive Cancer Center, University Medical City, Muscat, Oman.
George B J BusbyAllelica, Inc., New York, NY, USA.
Sulaiman Al-MahdhuriNational Records & Archives Authority, Muscat, Oman.
Mohammed Al-RawahiDepartment of Hematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Saif Al-HosniDepartment of Hematology, Sultan Qaboos University Hospital, University Medical City, Muscat, Oman.
Ali Al-MarhoobiDepartment of Hematology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
Ammar Al-SheriyaniRoyal Oman Police Hospital, Muscat, Oman.
Ellen M LefflerDepartment of Human Genetics, the University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address: leffler@genetics.utah.edu.

Funding

TRAINING PROGRAM IN GENETICST32GM007464 · NIGMS · UNIVERSITY OF UTAH · PI GRUNWALD, DAVID J., STANFIELD, GILLIAN · 1985 to 2020
$6.1M
University of Utah Genetics Training ProgramT32GM141848 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI GOLIC, KENT G, GRUNWALD, DAVID J. · 2021 to 2025
$2.9M
Genomic signatures of primate-pathogen interactionsR35GM147709 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Ellen Leffler · 2022 to 2026
$1.9M
From genomics to natural language processing: A protected environment for research computing in the health scienceS10OD021644 · OD · UNIVERSITY OF UTAH · PI CHEATHAM, THOMAS E. · 2017 to 2017
$494k
NIGMS NIH HHS R35 GM147709NIGMS NIH HHS T32 GM007464NIGMS NIH HHS T32 GM141848NIH HHS S10 OD021644
6 · The paper itself

Abstract

Malaria in humans is largely caused by two divergent species of Plasmodium parasites, P. vivax and P. falciparum, both of which have driven the spread of protective alleles in human populations. Notably, an erythrocyte-specific Duffy null allele (Fy

Indexed as

Duffy Blood-Group SystemMalaria, VivaxPlasmodium vivaxReceptors, Cell SurfaceAllelesGene FrequencyGenetics, PopulationHumansOmanPrevalenceSelection, GeneticACKR1 protein, humanDuffy Blood-Group SystemReceptors, Cell Surfaceadaptive admixtureAfricaDARCDuffy nullgenotypemalariaOmanpopulation genetics

Identifiers

PMID41881027
PMCPMC13078719

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.