Evidence map›Paper›PMID 41880602›Full record

ArticleJMIR formative research2026

Development and Evaluation of a Human-in-the-Loop Data Curation Training Program to Support a Digital Clinical Trial Platform: Descriptive Feasibility Study.

Mirna Issa, Olivia Yang, Jeffrey Doeve, Shreya Arcot, Amanda Chang, Shriya Amara, Shiven Himanshu Bhakta, Iman Baber, Kawan Shali, Qaiss Dweik and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JMIR formative research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mirna IssaDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0006-0748-6666
Olivia YangDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0008-2890-0728
Jeffrey DoeveDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0009-6466-1469
Shreya ArcotDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0005-8435-7721
Amanda ChangDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0000-0462-5700
Shriya AmaraDepartment of Neuroscience, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0003-7803-7356
Shiven Himanshu BhaktaDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0007-0345-9166
Iman BaberInstitute for Society and Genetics, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0009-6208-0660
Kawan ShaliDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0009-2536-2888
Qaiss DweikDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, United States.ORCID 0009-0007-2280-4025
Tony Kin Wai HungHartford HealthCare Cancer Institute, 85 Retreat Ave, Hartford, CT, 06106, United States, 1 860-972-4183.ORCID 0000-0002-3872-5512

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Background: LookUpTrials is a clinician-facing digital platform designed to support point-of-care navigation of institution-specific oncology clinical trials, incorporating artificial intelligence-assisted summarization and search functionalities. While embedding curated trial knowledge tools in community oncology workflows is feasible, the human infrastructure required to sustain high-quality, up-to-date trial data over time remains underexplored. Objective: This study aimed to evaluate the feasibility of a structured training program embedding trainees within a supervised human-in-the-loop workflow for oncology clinical trial data curation in support of the LookUpTrials digital platform. Methods: We conducted a descriptive feasibility evaluation of a cohort-based training and workflow model. A total of 10 undergraduate trainees curated publicly available trial information from institutional portals and ClinicalTrials.gov across 5 academic medical centers. Trial throughput and participant experiences were summarized descriptively. Results: Over 10 months, trainees curated 2503 oncology clinical trial entries across 5 institutions, with processing rates increasing over time. Participants reported that structured onboarding and peer support facilitated engagement with data curation workflows. Conclusions: Standardized human-in-the-loop workflows for clinical trial data stewardship can be implemented with individuals without prior clinical trials or informatics experience when supported by structured training and quality assurance. This study complements prior feasibility work on embedding trial knowledge tools in community oncology settings by focusing on the sustainability of the underlying content pipeline. Further evaluation is needed to assess scalability across institutions and durability over longer periods of platform maturation.

Indexed as

Clinical Trials as TopicData CurationFeasibility StudiesHumanscancerclinical trialsLookUpTrialsmobile appundergraduate students

Identifiers

PMID41880602
PMCPMC13016434

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.