Evidence map›Paper›PMID 41880574›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

DNA methylation site loss for plasticity-led novel trait genetic fixation.

Takafumi Katsumura, Suguru Sato, Kana Yamashita, Shoji Oda, Takashi Gakuhari, Shodai Tanaka, Kazuko Fujitani, Toshiyuki Nishimaki, Tadashi Imai, Yasutoshi Yoshiura and 7 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. DNA methylation site loss for plasticity-led novel trait genetic fixation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Takafumi KatsumuraDepartment of Anatomy, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.ORCID 0000-0001-7192-150X
Suguru SatoDepartment of Biological Sciences, Kitasato University School of Science, Sagamihara 252-0373, Japan.
Kana YamashitaDepartment of Biological Sciences, Kitasato University School of Science, Sagamihara 252-0373, Japan.
Shoji OdaDepartment of Integrated Biosciences, The University of Tokyo, Kashiwa 277-8562, Japan.
Takashi GakuhariInstitute of Human and Social Sciences, Kanazawa University, Kanazawa 920-1192, Japan.
Shodai TanakaDepartment of Biological Sciences, Kitasato University School of Science, Sagamihara 252-0373, Japan.
Kazuko FujitaniMolecular Biology Research Center, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.ORCID 0009-0008-2382-9643
Toshiyuki NishimakiDepartment of Anatomy, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.
Tadashi ImaiProduction Engineering Division, Fisheries Technology Institute, Japan Fisheries Research and Education Agency, Onomichi 722-0061, Japan.ORCID 0000-0001-8817-4467
Yasutoshi YoshiuraProduction Engineering Division, Fisheries Technology Institute, Japan Fisheries Research and Education Agency, Onomichi 722-0061, Japan.ORCID 0009-0002-3955-0053
Hirohiko TakeshimaDepartment of Marine Biology, Tokai University School of Biological Sciences, Shizuoka 424-8610, Japan.ORCID 0009-0000-0007-1333
Yasuyuki HashiguchiDepartment of Biology, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, Japan.
Yoichi SekitaDepartment of Biosciences, Kitasato University School of Science, Sagamihara 252-0373, Japan.ORCID 0000-0002-6230-8719
Hiroshi MitaniDepartment of Integrated Biosciences, The University of Tokyo, Kashiwa 277-8562, Japan.
Motoyuki OgawaDepartment of Anatomy, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.
Hideaki TakeuchiDepartment of Biological Science, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Hiroki OotaDepartment of Anatomy, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) JP16J07227MEXT | Japan Society for the Promotion of Science (JSPS) JP16K21352MEXT | Japan Society for the Promotion of Science (JSPS) JP17H01453MEXT | Japan Society for the Promotion of Science (JSPS) JP17H03738MEXT | Japan Society for the Promotion of Science (JSPS) JP19H05737MEXT | Japan Society for the Promotion of Science (JSPS) JP19K16201MEXT | Japan Society for the Promotion of Science (JSPS) JP24K02078
6 · The paper itself

Abstract

Phenotypic plasticity allows organisms to adapt traits in response to environmental changes, yet the molecular basis by which such plastic traits become genetically fixed remains unclear. Here, we investigated gut-length plasticity in medaka fish (

Indexed as

Adaptation, PhysiologicalDNA MethylationEvolution, MolecularOryziasAnimalsCpG IslandsCRISPR-Cas SystemsEpigenesis, GeneticFemaleFish ProteinsGastrointestinal TractMaleOrgan SizePhenotypeSeasonsFish ProteinsDNA methylationgenetic fixationmedaka fishphenotypic plasticity

Identifiers

PMID41880574
PMCPMC13037885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.