ArticleProceedings of the National Academy of Sciences of the United States of America2026
Endogenous ATP-powered nanomotors directing neural stem cell differentiation for Parkinson's disease treatment.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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9 authors.
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Abstract
Transplantation-free neuron regeneration remains attractive yet unsolved for reversing Parkinson's disease (PD). Here, we present enzyme-driven mesoporous gold nanomotors (Apyrase@Au) that leverage endogenous biochemical energy for spatiotemporally controlled promotion of neural stem cell (NSC) differentiation, without exogenous stem cell transplantation. By catalyzing endogenous adenosine triphosphate (ATP) hydrolysis, Apyrase@Au nanomotors simultaneously generate directional propulsion and localized signaling messenger protons. These protons induce calcium influx and activate quiescent NSCs within the ventricular-subventricular zone of PD mice, directing their differentiation into functional neurons and alleviating moving dysfunction. The bioenergy-converting system imparts dual functionality to active matter, propelling while concurrently yielding bioactive products. This work demonstrates the potential of ATP-powered nanomachines as a self-sustaining and targeted biointerface, offering a promising strategy for promoting NSC differentiation and alleviating moving dysfunction in degenerative diseases.
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