ReviewScience translational medicine2026
Beyond bystanders: How β cell stress shapes the autoimmune response in T1D.
Review in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Deletion of the T1D risk geneBiochemistry and biophysics reports · 2026Article
- The β-cells in type 1 diabetes mellitus: findings from human pancreas studies.Nature reviews. Endocrinology · 2026Review
- Shared non-HLA genetic architecture across diverse ancestries links insulin secretion and resistance to type 1 diabetes.Diabetologia · 2026Article
- Oxidative Post-Translational Modifications of Insulin in Type 1 Diabetes Autoimmunity.Immunological reviews · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
For many years, research focused on the immune system's role in the development of type 1 diabetes (T1D). However, mounting evidence suggests a critical involvement of intrinsic pancreatic β cell defects, particularly impaired cellular stress responses, in disease pathology. This shift in understanding is supported by the limited effectiveness of immune-targeting therapies, which have so far managed to delay, rather than prevent or cure, T1D. Here, we discuss why the immune system specifically targets β cells, how stress pathways modify the interaction between β cells and immune cells, β cell resilience, and challenges and opportunities in targeting β cell stress in T1D.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.