Evidence map›Paper›PMID 41880517›Full record

ArticleScience translational medicine2026

LSD1 inhibition ameliorates congenital dyserythropoietic anemia type II.

Lei Yu, Yu Wang, Richard King, Greggory Myers, Kaiwen Deng, Beth McGee, Ann Friedman, Ginette Balbin-Cuesta, Zesen Lin, Claire Drysdale and 9 more

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lei YuDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0005-4897-1265
Yu WangDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Richard KingDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0519-8776
Greggory MyersDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-2810-8091
Kaiwen DengComputational and Medical Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-0365-6278
Beth McGeeDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5786-7164
Ann FriedmanDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4915-4038
Ginette Balbin-CuestaCellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1062-6774
Zesen LinDepartment of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA.
Claire DrysdaleDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Xiaofang LiuDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Joseph C MinDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Claire KerpetDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Yuanfang GuanComputational and Medical Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Patrick J GallagherDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Ayse Bilge OzelDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1112-4258
Aaron RobidaCenter for Chemical Genomics, Life Sciences Institute, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4867-9641
James Douglas EngelDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-9593-1825
Rami KhoriatyDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-2539-5953

Funding

CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
The molecular pathophysiology of the congenital dyserythropoietic anemiasR01HL148333 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Rami Khoriaty · 2019 to 2026
$4.6M
Training CoreTL1DK136046 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Laura H Mariani · 2022 to 2026
$2.5M
The regulation of thrombopoietin levelsR01HL157062 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHORIATY, RAMI · 2021 to 2024
$2.1M
University of Michigan Kidney, Urology and Hematology Research Training NetworkU2CDK129445 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BENJAMIN L MARGOLIS · 2022 to 2026
$2.0M
Reactivation of Gamma Globin Expression in β-HemoglobinopathiesF31HL162544 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BALBIN-CUESTA, GINETTE THERESA · 2022 to 2023
$79k
NHLBI NIH HHS F31 HL162544NHLBI NIH HHS R01 HL148333NHLBI NIH HHS R01 HL157062NIDDK NIH HHS TL1 DK136046NIDDK NIH HHS U2C DK129445NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

Congenital dyserythropoietic anemia type II (CDAII) is an autosomal recessive disease resulting from loss-of-function mutations in

Indexed as

Anemia, Dyserythropoietic, CongenitalHistone DemethylasesAnimalsCell DifferentiationCell LineErythroid CellsHematopoietic Stem CellsHumansMiceVesicular Transport ProteinsHistone DemethylasesKDM1A protein, humanSEC23B protein, humanVesicular Transport Proteins

Identifiers

PMID41880517
PMCPMC13273767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.