In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Sarah M BernhardCenter for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-8549-0413 Susovan Roy ChowdhuryCenter for Investigation of Membrane Excitability Diseases, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-7068-6464 Tsuyoshi MurataDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-9506-117X Erin L ReinlDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-8500-872X Nokomis Ramos-GonzalezCenter for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9398-8956 Elizabeth DennCenter for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Kevin AppourchauxCenter for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-9853-3347 Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan.ORCID 0000-0003-0805-4049 Sarah K EnglandDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-4247-0281 Jonathan F FayDepartment of Biochemistry and Molecular Biology, University of Maryland Baltimore, Baltimore, MD, USA.ORCID 0000-0003-1822-2384 Susruta MajumdarCenter for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2931-3823 Baron ChandaCenter for Investigation of Membrane Excitability Diseases, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-4954-7034 Tao CheCenter for Clinical Pharmacology, Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1620-3027 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The delta opioid receptor (DOR) is a promising target for treating pain, anxiety, and depression, yet no DOR-based drugs have reached the clinic. Here, we examine how ligands with varying therapeutic properties modulate DOR function. While full agonists rapidly internalize the receptor, partial agonists show a slower rate of internalization, and antagonists increase cell-surface DOR levels. High-resolution structures of ligand-bound DOR-G
Indexed as
Receptors, Opioid, deltaAnimalsFluorescence Resonance Energy TransferHumansLigandsModels, MolecularProtein BindingProtein ConformationLigandsReceptors, Opioid, delta
Identifiers
PMID41880505
PMCPMC13015893
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
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