ArticleMemorias do Instituto Oswaldo Cruz2026
Effects of exposure to Rickettsia bellii on reservoir competence of guinea pigs for Rickettsia rickettsii
Article in Memorias do Instituto Oswaldo Cruz, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A real-time PCR assay for detection of Rickettsia rickettsii to aid in vivo infection monitoring.International journal of medical microbiology : IJMM · 2026Article
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10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAmblyomma sculptum is the main vector implicated in the transmission of Rickettsia rickettsii in southeastern Brazil, where capybaras are known to be the main amplifying hosts of this pathogen. Interestingly, many areas inhabited by large populations of capybaras and A. sculptum remain free of R. rickettsii, suggesting that other drivers may be involved in the pathogen perpetuation. A. sculptum frequently occurs in sympatry with Amblyomma dubitatum ticks, sharing the same hosts with them. Considering that A. dubitatum ticks are frequently infected with Rickettsia bellii, a possible interference of R. bellii in the reservoir competence of capybaras for R. rickettsii could explain the heterogeneous distribution of R. rickettsii in A. sculptum populations in southeastern Brazil.
objectivesThe present study aimed to evaluate the effect of primary exposure to R. bellii-infected A. dubitatum on the reservoir competence for R. rickettsii using guinea pigs as experimental models.
methodsThree guinea pigs were infested with R. bellii-infected A. dubitatum (Group GB), four guinea pigs with uninfected A. dubitatum (Group GD), and three guinea pigs were not exposed to A. dubitatum (Group GC). After infestation with A. dubitatum, all guinea pigs were exposed to one single R. rickettsii-infected A. sculptum female and then were infested with uninfected A. sculptum larvae. After ecdysis, nymphs were tested for detection of spotted fever group rickettsiae.
findingsFive out of six guinea pigs from GD and GC groups died, while one out of three guinea pigs in the GB group had a fatal outcome. R. rickettsii infection rate among ticks fed on animals from GB group was 21% (17/80), significantly lower than the rate of 54% (60/111) recorded in ticks fed on animals from GD and GC groups. MAIN
conclusionsPrior exposure of guinea pigs to R. bellii-infected A. dubitatum ticks reduced their reservoir competence for R. rickettsii.
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