ArticleArquivos brasileiros de cardiologia2026
Diagnostic Value of Serum sCD40L, CCL3, and NT-ProBNP Levels in Detection of Lower Limb Venous Thrombosis among Elderly Patients with Heart Failure.
Article in Arquivos brasileiros de cardiologia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Serum Levels of sCD40L, CCL3, and NT-proBNP in Elderly Patients Admitted to the Hospital with HF.Arquivos brasileiros de cardiologia · 2026Article
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4 authors.
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Abstract
backgroundThe serum levels of soluble CD40 ligand (sCD40L), cytokine ligand 3 (CCL3), and N-terminal pro-brain natriuretic peptide (NT-proBNP) are closely associated with heart failure (HF).
objectiveThis study evaluated the predictive value of serum sCD40L, CCL3, and NT-proBNP levels for lower limb venous thrombosis (LLVT) in elderly patients with HF.
methodsA total of 200 patients with HF were retrospectively included and equally divided into thrombus and non-thrombus groups based on lower limb vein ultrasound findings. Serum levels of sCD40L, CCL3, and NT-proBNP were measured and analyzed. A p-value < 0.05 was considered statistically significant.
resultsSerum sCD40L, CCL3, and NT-proBNP levels were significantly higher in the thrombus group compared with the non-thrombus group (p < 0.05). Multivariate logistic regression analysis demonstrated that elevated serum sCD40L, CCL3, and NT-proBNP levels are risk factors for LLVT in patients with HF (p < 0.05). The area under the receiver operating characteristic (ROC) curve (AUC) for the combined serum sCD40L, CCL3, and NT-proBNP levels was greater than that of each individual marker (Z values: sCD40L = 3.337, CCL3 = 2.303, and NT-proBNP = 5.156; p < 0.001, p < 0.001, and p = 0.021, respectively).
conclusionElevated serum sCD40L, CCL3, and NT-proBNP levels were associated with LLVT in elderly patients with HF. The combination of these markers provides high diagnostic value for the detection of LLVT in this population.
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