ArticleRevista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo2026
Impact of congenital anomalies on infant mortality in the 14th Health Region of Paraná, from 2010 to 2019.
Article in Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe aim of this study was to describe congenital anomaly (CA) notifications at birth, evaluating their impact on infant mortality in northwest Paraná.
methodsThis is a cross-sectional study using linked data on births with CA and deaths due to these conditions in the 14th Health Region of Paraná, Brazil (2010-2019), obtained through the linkage of data from the Live Birth Information System (Sinasc) and the Mortality Information System (SIM).
resultsA total of 216 live births (LBs) with CAs were identified in Sinasc (57.7/10,000 LBs), of which 71.8% were isolated anomalies and 28.2% were multiple anomalies, totaling 331 reported anomalies. Limb and musculoskeletal defects were the most frequent (25.7%). After linking Sinasc and SIM, congenital heart defects (CHDs), initially ranked seventh, became the second most prevalent CA. A total of 115 infant deaths due to CA were identified, resulting in an infant mortality rate (IMR) of 30.7/10,000 LBs, with CHDs and neural tube defects (NTDs) as the leading causes. The data linkage revealed 55 deaths with CAs not recorded in Sinasc, increasing prevalence to 72.4/10,000 LBs (+25.5%).
conclusionsIMR for CAs in the region exceeded the national average (28.0/10,000 LBs), highlighting the importance of linking data to strengthen epidemiological surveillance of these conditions. CHDs and NTDs were the most frequent causes of infant deaths associated with CAs, reinforcing the need to improve early detection and the recording of these cases to reduce infant mortality due to CAs across different regions of Brazil.
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