ArticlePLoS neglected tropical diseases2026
A novel method for establishing a mouse model of hepatic echinococcosis: Ultrasound-guided percutaneous liver puncture modeling.
Article in PLoS neglected tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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10 authors.
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Abstract
introductionResearch on hepatic echinococcosis relies on stable, reproducible animal models. Traditional open-laparotomy modeling presents issues such as significant trauma and poor consistency.
objectiveTo compare the efficacy and safety of ultrasound-guided percutaneous liver puncture inoculation versus traditional open-laparotomy in establishing a hepatic echinococcosis model in C57BL/6 mice.
methodsAlveolar echinococcus (AE) cystic larvae or cystic echinococcus (CE) scolices were implanted into mouse livers using ultrasound-guided percutaneous liver puncture inoculation and traditional open surgery, respectively. Postoperative dynamic ultrasound monitoring, histopathology, and immunofluorescence staining were employed for systematic evaluation.
resultsThe survival rate in the ultrasound-guided group reached 100% (30/30), significantly higher than the 80% (24/30) in the surgical group, representing a difference of 20 percentage points (95% CI: 5.7% to 34.3%; p = 0.039). The complication rate was only 6.7% (2/30) in the ultrasound-guided group, compared to 20% (6/30) in the surgical group, with a difference of -13.3 percentage points (95% CI: -30.2% to 3.6%; p = 0.133). Ultrasound-guided modeling achieved a 100% success rate, with more uniform lesion growth and accelerated progression. Histopathology revealed more typical fibrosis and immune microenvironment characteristics.
conclusionUltrasound-guided percutaneous liver biopsy offers advantages including short procedure duration, minimal trauma, and high model consistency. It significantly enhances modeling efficiency while reducing surgical interference, providing a more reliable animal model platform for hepatic echinococcosis research.
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