Evidence map›Paper›PMID 41880157›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Redox robustness drives LPMO evolution.

Iván Ayuso-Fernández, Tom Z Emrich-Mills, Ole Golten, Zarah Forsberg, Kelsi R Hall, László G Nagy, Morten Sørlie, Åsmund Kjendseth Røhr, Vincent G H Eijsink

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Iván Ayuso-Fernández *Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1432, Norway.ORCID 0000-0001-8503-2615
Tom Z Emrich-Mills *Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1432, Norway.ORCID 0000-0002-4440-626X
Ole GoltenFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1432, Norway.ORCID 0000-0002-0321-4835
Zarah ForsbergFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1432, Norway.ORCID 0000-0002-8236-7986
Kelsi R HallFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1432, Norway.ORCID 0000-0001-5611-3010
László G NagySynthetic and Systems Biology Unit, Institute of Biochemistry, Hungarian Research Network Biological Research Centre Szeged, Szeged 6726, Hungary.
Morten SørlieFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1432, Norway.ORCID 0000-0001-7259-6710
Åsmund Kjendseth RøhrFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1432, Norway.
Vincent G H EijsinkFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås 1432, Norway.ORCID 0000-0002-9220-8743

Funding

EC | ERC | HORIZON EUROPE European Research Council (ERC) 101086900EC | European Research Council (ERC) 856446The Norwegian Macromolecular Crystallography Consortium 245828The Research Council of Norway 301022
6 · The paper itself

Abstract

Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are exceptionally powerful small redox enzymes that master the controlled generation and productive use of potentially damaging hydroxyl radicals in what is essentially a H

Indexed as

Evolution, MolecularMixed Function OxygenasesCopperHydrogen PeroxideModels, MolecularMutationOxidation-ReductionCopperHydrogen PeroxideMixed Function Oxygenasesancestral sequence reconstructionbacterial chitin oxidationlytic polysaccharide monooxygenasesredox robustness evolution

Identifiers

PMID41880157
PMCPMC12818417

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.