Evidence map›Paper›PMID 41880092›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Dissecting Alzheimer's disease heritability across populations.

Shiying Liu, William S Bush, Brian W Kunkle, Goldie S Byrd, Christiane Reitz, Giuseppe Tosto, Farid Rajabli, Allison M Caban-Holt, Michael Cuccaro, Takiyah Starks and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shiying LiuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
William S BushDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Brian W KunkleJohn P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Goldie S ByrdMaya Angelou Center for Health Equity, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Christiane ReitzGertrude H. Sergievsky Center, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology Columbia University, Department of Epidemiology, Columbia University, New York, New York, USA.
Giuseppe TostoThe Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, Columbia University; Department of Neurology, Columbia University Irving Medical Center, Columbia University; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York, USA.
Farid RajabliJohn P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Allison M Caban-HoltMaya Angelou Center for Health Equity, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Michael CuccaroJohn P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Takiyah StarksMaya Angelou Center for Health Equity, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Larry D AdamsJohn P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Briseida E FelicianoUniversidad Central del Caribe, Bayamón, Puerto Rico, USA.
Rufus AkinyemiNeuroscience and Ageing Research Unit, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Jeffery M VanceJohn P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Margaret Pericak-VanceJohn P. Hussman Institute for Human Genomics, Dr. John T. Macdonald Foundation Department of Human Genetics, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Jonathan L HainesDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Dana C CrawfordDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID 0000-0002-6437-6248
Scott M WilliamsDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID 0000-0002-4835-9544

Funding

Recruitment and Retention for Alzheimer's Disease Diversity Genetic Cohorts in the ADSP (READD-ADSP)U19AG074865 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Giuseppe Tosto · 2022 to 2026
$55.3M
The Origins of Alzheimer Disease in African AmericansR01AG072547 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Rufus Olusola Akinyemi, GOLDIE S. BYRD · 2022 to 2026
$26.1M
The Alzheimer Disease Sequence Analysis CollaborativeU01AG058654 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI BUSH, WILLIAM S, FARRER, LINDSAY A. · 2018 to 2022
$14.6M
Diana Jacobs Kalman/AFAR for Research in the Biology of AgingNIA NIH HHS R01 AG072547NIA NIH HHS R01AG072547NIA NIH HHS U01AG058654NIA NIH HHS U19 AG074865NIA NIH HHS U19AG074865
6 · The paper itself

Abstract

introductionLate-onset Alzheimer's disease (LOAD) is highly heritable; however, its estimated incidence across populations remains unclear.

methodsWe computed family-based heritability leveraging Alzheimer's Disease Sequencing Project pedigrees from non-Hispanic White (404 pedigrees), non-Hispanic Black (13 pedigrees), Dominican (100 pedigrees), and Dutch isolate (10 pedigrees), with four models incorporating age, sex, apolipoproten E epsilon4 (APOE ε4), and contributing study using two methods.

resultsHeritability estimates varied by method, model, and study populations. Statistical Analysis for Genetic Epidemiology (S.A.G.E.) estimates were highest for Dutch isolate (78.3%), followed by non-Hispanic Blacks (39.1%), Dominicans (31.7%), and non-Hispanic Whites (29.1%), adjusted for age and sex. APOE adjustment reduced estimates (4.9% on average), while study adjustment primarily affected groups that included multiple studies. Sequential Oligogenic Linkage Analysis Routines (SOLAR-Eclipse) estimates were higher (45.2% to 80.2%) than S.A.G.E. (20.4% to 80.9%) but behaved in parallel, except for the Dutch isolate. DISCUSSION: LOAD heritability estimates are dependent on study population and may reflect or indicate differences in LOAD risk by population.

Indexed as

Alzheimer DiseaseGenetic Predisposition to DiseaseAgedApolipoprotein E4Black PeopleCaribbean PeopleEuropean PeopleFemaleHumansMaleNetherlandsPedigreeWhite PeopleApolipoprotein E4APOE ε4cohortfamily‐basedheritabilitymultiple populations

Identifiers

PMID41880092
PMCPMC13093350

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.