Evidence map›Paper›PMID 41880065›Full record

ArticleBrain informatics2026

U-Net-based transfer learning for automated tumour segmentation enabling fully automated [

Michele Mureddu, Rosella Trò, Federico Giovanni Garau, Nicolò Trebino, Andrea Bianconi, Andrea Rossi, Antonia Ramaglia, Antonio Verrico, Claudia Milanaccio, Giovanni Morana and 4 more

Abstract read
In one paragraph

Article in Brain informatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michele Mureddu *Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, Via all'Opera Pia 13, 16145, Genoa, Italy. michele.mureddu@edu.unige.it.ORCID http://orcid.org/0009-0005-2334-6850
Rosella Trò *Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, Via all'Opera Pia 13, 16145, Genoa, Italy.ORCID http://orcid.org/0000-0002-4915-5295
Federico Giovanni GarauDepartment of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, Via all'Opera Pia 13, 16145, Genoa, Italy.
Nicolò TrebinoDepartment of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, Via all'Opera Pia 13, 16145, Genoa, Italy.
Andrea BianconiU.O. Clinica Neurochirurgica e Neurotraumatologica, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.
Andrea RossiNeuroRadiology Unit, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genoa, Italy.
Antonia RamagliaNeuroRadiology Unit, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genoa, Italy.
Antonio VerricoNeuro-Oncology Unit, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genoa, Italy.
Claudia MilanaccioNeuro-Oncology Unit, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini 5, 16147, Genoa, Italy.
Giovanni MoranaDepartment of Neurosciences, University of Turin, Via Cherasco 15, 10126, Turin, Italy.
Massimiliano IacozziNuclear Medicine Unit, Ente Ospedaliero Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy.
Francesco FizNuclear Medicine Unit, Ente Ospedaliero Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy.
Arnoldo Piccardo *Nuclear Medicine Unit, Ente Ospedaliero Ospedali Galliera, Mura delle Cappuccine 14, 16128, Genoa, Italy.
Marco Massimo Fato *Department of Informatics, Bioengineering, Robotics and System Engineering (DIBRIS), University of Genoa, Via all'Opera Pia 13, 16145, Genoa, Italy.

Funding

The Italian Ministry of Health and by Regione Liguria Ricerca Finalizzata di Rete NET-2019-12371188 GLI-HOPE
6 · The paper itself

Abstract

backgroundPET imaging with [

methodsWe evaluated whether a deep learning model, leveraging transfer learning from adult glioma datasets, could enable a fully automated pipeline for tumour segmentation and PET parameter extraction. Static and dynamic parameters were compared across three approaches: (i) automatic vs semi-automatic, (ii) automatic vs manual, and (iii) manual vs. semi-automatic. Data from 103 paediatric patients (median age 11 years; 54 females, 49 males) with static and/or dynamic [

resultsThe best model achieved a Dice score of 0.82 ± 0.11 and was integrated into the pipeline for extracting static and dynamic indices. Automatic Tumour-to-Striatum ratio showed high reproducibility across comparisons ((i) p = 0.660, (ii) p = 0.342, (iii) p = 0.639), while Tumour-to-Background differed significantly when comparing manual delineations (p < 0.01). Dynamic parameters demonstrated good reproducibility with the automatic method (p > 0.05). Importantly, both automated static indices correlate significantly with tumour grade, with the overall and progression-free survival (p < 0.05).

conclusionsTransfer learning enabled a fully automatic [

Indexed as

[18F]F DOPA PETAutomated pipelineFLAIR MRIPaediatric gliomasTransfer learningU-Net

Identifiers

PMID41880065
PMCPMC13083549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.