Evidence map›Paper›PMID 41879938›Full record

ArticleGeroScience2026

Distinct effects of aging and klotho deletion on the choroid plexus.

Zahra Fanaei-Kahrani, Tushar Patel, Christina Valkova, Alexander Gloria, Justine Wagner, Heike Heuer, Markus Schwaninger, Steve Hoffmann, Reinhard Bauer, Christoph Kaether

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zahra Fanaei-KahraniLeibniz Institut für Alternsforschung-Fritz Lipmann Institut (FLI), Beutenbergstr. 11, 07745, Jena, Germany.
Tushar PatelLeibniz Institut für Alternsforschung-Fritz Lipmann Institut (FLI), Beutenbergstr. 11, 07745, Jena, Germany.
Christina ValkovaLeibniz Institut für Alternsforschung-Fritz Lipmann Institut (FLI), Beutenbergstr. 11, 07745, Jena, Germany.
Alexander GloriaInstitute of Molecular Cell Biology, Center for Molecular Biomedicine, University Hospital Jena, Jena, Germany.
Justine WagnerLeibniz Institut für Alternsforschung-Fritz Lipmann Institut (FLI), Beutenbergstr. 11, 07745, Jena, Germany.
Heike HeuerDepartment of Endocrinology, Diabetes and Metabolism and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University Duisburg Essen, Essen, Germany.
Markus SchwaningerInstitute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany.
Steve HoffmannLeibniz Institut für Alternsforschung-Fritz Lipmann Institut (FLI), Beutenbergstr. 11, 07745, Jena, Germany.
Reinhard BauerInstitute of Molecular Cell Biology, Center for Molecular Biomedicine, University Hospital Jena, Jena, Germany.
Christoph KaetherLeibniz Institut für Alternsforschung-Fritz Lipmann Institut (FLI), Beutenbergstr. 11, 07745, Jena, Germany. christoph.kaether@leibniz-fli.de.ORCID http://orcid.org/0000-0002-6874-2276

Funding

Deutsche Forschungsgemeinschaft RTG 2155 ProMoAge
6 · The paper itself

Abstract

Klotho (Kl) is an anti-aging protein primarily produced in the kidney and the choroid plexus (CP, where it regulates cerebrospinal fluid composition and exerts neuroprotective effects. Here, we investigated the age-dependent consequences of a CP-specific Kl deletion on CP structure and function using mice lacking Kl exclusively in CP epithelial cells (Kl

Indexed as

AgingChoroid PlexusGlucuronidaseAnimalsCalcinosisKlotho ProteinsMaleMiceGlucuronidaseKlotho ProteinsAgingChoroid plexus (CP)Klotho (Kl)

Identifiers

PMID41879938
PMCPMC13356169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.