ArticleBiogerontology2026
Polysaccharide-mediated aging-modulatory effects of Labisia Pumila extracts on the physiological changes in C. elegans and D. melanogaster.
Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Polysaccharides are natural macromolecules with diverse bioactivities and potential health benefits. It exhibits a broad spectrum of biological effects, with extensive research supporting their antioxidative, anti-inflammatory, immunomodulatory, and anti-aging properties. The study evaluated the aging-modulatory effects of Labisia pumila polysaccharides (LPP) using Caenorhabditis elegans (C. elegans) and Drosophila melanogaster (D. melanogaster) as model organisms. LPP treatment increased the lifespan of in both models, enhanced locomotor activity and improved stress tolerance under the variety stress conditions. The researches using C. elegans mutant strains suggested that these effects are associated with the conserved stress response pathways DAF-16 and SOD-3, indicating potential involvement in cellular defense mechanisms. Metabolomic profiling further indicated increased levels of antioxidant metabolites and altered energy metabolism pathways, suggesting improved cellular homeostasis. These effects align with hormesis, in which mild stress induced by LPP triggers endogenous protective mechanisms to enhance physiological resilience. Overall, the results show that LPP modulates aging through integrated changes at the behavioral, genetic, and metabolic levels, offering a mechanistic foundation for its potential use as a safe and effective natural agent in promoting healthy aging.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.