ReviewThe Journal of cell biology2026
Structure and function of the synaptonemal complex.
Review in The Journal of cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A mammalian-specific domain of MSH5 drives the transition from crossover licensing to designation during meiotic prophase I.bioRxiv : the preprint server for biology · 2026Article
- Prophase roles of replication protein A in crossover formation and meiotic progression.Journal of microbiology (Seoul, Korea) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
A defining feature of meiosis is the synaptonemal complex (SC), a zipper-like protein structure that forms between homologous chromosomes to regulate their recombination and segregation. Historically viewed as an enigmatic electron-dense scaffold, the SC is now recognized as a dynamic signaling platform that coordinates key meiotic processes. Here, we review recent advances in understanding SC structure and function. We describe diverse complementary approaches that have expanded the catalog of SC components and their network of interactions within this architecture. We highlight striking conservation in structural organization and ancient molecular modules that couple SC structure to crossover regulation and further discuss how the SC implements feedback mechanisms controlling meiotic DNA break formation and repair capacity to ensure faithful chromosome segregation across generations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.