Evidence map›Paper›PMID 41879608›Full record

ArticleJACC. Case reports2026

Unilateral Renal Denervation for Refractory Hypertension in Aortic Dissection.

Xian-Geng Hou, Jun-Shi Zhang, Guang-Mei Hu, Ying-Ying Zheng, Xiang Ma, Yi-Tong Ma, Xiang Xie

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xian-Geng HouHypertension Department, Cardiovascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China; Key Laboratory of Hypertension Research of Xinjiang Medical University, Urumqi, China; Key Laboratory of High Incidence Disease Research in Xingjiang (Xinjiang Medical University), Ministry of Education, Urumqi, China.
Jun-Shi ZhangHypertension Department, Cardiovascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China; Key Laboratory of Hypertension Research of Xinjiang Medical University, Urumqi, China.
Guang-Mei HuHypertension Department, Cardiovascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China; Key Laboratory of Hypertension Research of Xinjiang Medical University, Urumqi, China.
Ying-Ying ZhengHypertension Department, Cardiovascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China; Key Laboratory of Hypertension Research of Xinjiang Medical University, Urumqi, China; Cardiac Rehabilitation Department, Cardiovascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Xiang MaCardiovascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Yi-Tong MaCardiovascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Xiang XieHypertension Department, Cardiovascular Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China; Key Laboratory of Hypertension Research of Xinjiang Medical University, Urumqi, China; Key Laboratory of High Incidence Disease Research in Xingjiang (Xinjiang Medical University), Ministry of Education, Urumqi, China. Electronic address: xiangxie999@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroudRefractory hypertension in patients with aortic dissection represents an extreme therapeutic challenge, as these patients are typically excluded from renal denervation (RDN) trials due to prohibitive procedural risks. CASE SUMMARY: A 40-year-old man with refractory hypertension complicated by a chronic DeBakey Type III (Stanford Type B) aortic dissection and abdominal aortic aneurysm presented with blood pressure of 171/98 mm Hg despite quintuple therapy. Unilateral right-sided RDN was performed using a multielectrode catheter, delivering 24 ablation lesions. Postprocedure, systolic blood pressure decreased by 30 mm Hg, enabling discontinuation of 2 antihypertensive agents. DISCUSSION: This case demonstrates that unilateral RDN is safe and effective in patients with extreme vascular lesions where bilateral RDN is not suitable. The marked blood pressure response suggests heightened sympathetic drive in this population. TAKE-HOME MESSAGE: RDN is also feasible for patients with aortic dissection, and even unilateral RDN can achieve a blood pressure-lowering effect. These findings are hypothesis-generating and require prospective validation.

Indexed as

aortic dissectionrefractory hypertensionrenal denervation

Identifiers

PMID41879608
PMCPMC13130937

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.