Evidence map›Paper›PMID 41879597›Full record

ArticleJACC. Case reports2026

Intermittent High-Grade Atrioventricular Block as a Presenting Sign of Left Ventricular Noncompaction.

Mashkurul Haque, Aubriannah Larson, Ola Abdelkarim, Vikram Sharma

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mashkurul HaqueDepartment of Internal Medicine, University of Iowa Health Care, Iowa City, Iowa, USA. Electronic address: mashkurul-haque@uiowa.edu.
Aubriannah LarsonDepartment of Internal Medicine, University of Iowa Health Care, Iowa City, Iowa, USA.
Ola AbdelkarimDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Health Care, Iowa City, Iowa, USA.
Vikram SharmaDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Iowa Health Care, Iowa City, Iowa, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft ventricular noncompaction is characterized by excessive trabeculation and is variably associated with heart failure, arrhythmias, thromboembolism, and conduction disease. CASE SUMMARY: A 37-year-old man with palpitations and chest discomfort had intermittent high-grade (Mobitz II) atrioventricular block on event monitoring (3.7-second pause). Cardiac magnetic resonance revealed apicolateral hypertrabeculation with a diastolic noncompacted:compacted ratio of 3.5 without late gadolinium enhancement; transthoracic echocardiography showed preserved ejection fraction (60%). Electrophysiology recommended longitudinal rhythm surveillance with an implantable loop recorder; pacemaker was deferred. Genetic testing was advised but not authorized by insurance. DISCUSSION: Intermittent high-grade atrioventricular block can be an initial manifestation of left ventricular noncompaction with preserved systolic function. Recognition of this association supports advanced imaging in unexplained conduction disease in young adults and favors loop-recorder-guided surveillance with multidisciplinary follow-up, including genetics. TAKE-HOME MESSAGES: Unexplained high-grade atrioventricular block in a young adult should prompt advanced structural evaluation-including cardiac magnetic resonance-to exclude left ventricular noncompaction and other cardiomyopathies. Preserved ejection fraction and absent late gadolinium enhancement can coexist with clinically relevant conduction disease in left ventricular noncompaction. Implantable loop recorder-guided surveillance enables individualized timing of device therapy and complements genetic evaluation and cascade family screening.

Indexed as

cardiac magnetic resonancecardiomyopathyimagingleft ventricle

Identifiers

PMID41879597
PMCPMC13130902

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.