ArticleCurrent pharmaceutical design2026
Development and Characterisation of
Article in Current pharmaceutical design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
Funding
Abstract
introductionOral fast melt films (OFMF) present a convenient and user-friendly delivery system that supports oral health maintenance, improves patient compliance, and promotes accessible preventive care. Bacillus coagulans, a probiotic known for its dental health benefits, holds promise in addressing the global burden of oral diseases. This study aims to develop and characterise OFMF incorporating Bacillus coagulans for daily oral health support.
methodsNineteen OFMF formulations were prepared using varying ratios of carboxymethyl cellulose (CMC), hydroxypropyl methylcellulose (HPMC), and polyvinyl alcohol (PVA), along with PEG 400 and glycerine, via solvent casting followed by freeze-drying. The optimised PVA-based film was enriched with Bacillus coagulans, sucrose, citric acid, and mint water. Films were characterised using SEM, DSC, and PXRD, and evaluated for physicochemical, mechanical, disintegration, and probiotic viability.
resultsThe final OFMF formulation exhibited smooth morphology, average weight of 0.139 ± 0.00076 g, thickness of 0.4 ± 0.011 mm, tensile strength of 0.016 ± 0.00064 MPa, extension strain of 69.6 ± 16.84%, Young's modulus of 0.024 ± 0.0060 MPa, folding endurance >100 folds, pH of 6, and rapid disintegration time of 3 ± 0.52 seconds. DISCUSSION: The formulation demonstrated excellent mechanical integrity, rapid disintegration, and sustained probiotic viability. These findings support its potential for daily oral health maintenance, though further in vivo validation is warranted.
conclusionThe developed OFMFs provide a stable, effective, and user-friendly platform for delivering Bacillus coagulans, with strong potential for routine oral health supplementation.
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