Evidence map›Paper›PMID 41879344›Full record

ArticleShock (Augusta, Ga.)2026

Neutrophil Transcriptomic Changes in Severe Sterile Vasoplegic Syndrome Resemble a Distinct Molecular Subtype of Septic Shock.

Anaar E Siletz, Kindra M Kelly-Scumpia, Phillip O Scumpia, Kelly Street, Vasileios Ragkousis, Roksana Shirazi, Yas Sanaiha, Tran H Do, Richard Shemin, Murray Kwon and 5 more

Abstract read
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In one paragraph

Article in Shock (Augusta, Ga.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Anaar E SiletzDepartment of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California.
Kindra M Kelly-ScumpiaDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Phillip O ScumpiaDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Kelly StreetDepartment of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, California.
Vasileios RagkousisDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Roksana ShiraziDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Yas SanaihaDivision of Cardiac Surgery, Department of Surgery, University of California, Los Angeles, California.
Tran H DoDepartment of Dermatology, University of Michigan, Ann Arbor, Michigan.
Richard SheminDivision of Cardiac Surgery, Department of Surgery, University of California, Los Angeles, California.
Murray KwonDivision of Cardiac Surgery, Department of Surgery, University of California, Los Angeles, California.
Sara CragerDepartment of Emergency Medicine, University of California, Los Angeles, California.
Peyman BenharashDivision of Cardiac Surgery, Department of Surgery, University of California, Los Angeles, California.
H Gill CryerDepartment of Surgery, Ronald Reagan UCLA Medical Center, David Geffen School of Medicine, UCLA, Los Angeles, California.
J Perren CobbDepartment of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California.
Stephen T SmaleDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUnderstanding early molecular events in systemic inflammation in sepsis is complicated by host-pathogen interactions and responses over time. Vasoplegic syndrome after cardiac surgery resembles septic shock but lacks pathogen-related variables and proceeds over a defined, reproducible time course. We hypothesized that human neutrophil transcriptomic changes in vasoplegic syndrome would resemble one or more molecular subtypes of septic shock.

methodsWe compared dynamic human neutrophil transcriptomic changes during the development of vasoplegic syndrome to 1) dynamic changes in uncomplicated cardiac surgery and 2) static transcriptomic profiles in septic shock. Vasoplegic syndrome was defined as a vasopressor requirement to maintain mean arterial pressure >60 mmHg, cardiac index >2.2 L/min/m 2 , and systemic vascular resistance index <1,970 d·s/cm 5 ·m 2 lasting at least 24 hours postoperatively. Septic shock was defined as acute refractory organ dysfunction due to infection. Neutrophil transcriptomics were correlated with clinical course and plasma cytokine levels.

resultsIn principal component analysis, neutrophil transcriptomes from surgical patients demonstrated core gene expression changes in response to cardiac surgery independent of outcome. Additionally, among vasoplegic patients, two marked and consistent neutrophil transcriptomic phenotypes were observed and associated with distinct clinical phenotypes. A subset of dynamic expression changes in severe vasoplegic syndrome, which were not seen in surgical controls, instead resembled expression in patients with septic shock with increased matrix metalloproteinase 8 messenger RNA.

conclusionsDynamic gene expression in neutrophils from patients with severe vasoplegic syndrome includes both changes in response to surgery and the development of a gene expression phenotype resembling septic shock with elevated matrix metalloproteinase 8 expression. Our findings suggest a common neutrophil molecular program associated with multiorgan failure, which may include common therapeutic targets for both sterile and septic systemic inflammatory states.

Indexed as

NeutrophilsShock, SepticTranscriptomeVasoplegiaAgedFemaleHumansMaleMiddle AgedDysregulated inflammationneutrophilseptic shocktranscriptomevasoplegic syndrome

Identifiers

PMID41879344
PMCPMC13132051

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.