Trial reportThe Australian & New Zealand journal of obstetrics & gynaecology2026
Evaluating the Effectiveness of a Cervical Pessary to Improve Neonatal Outcome by Preventing Preterm Birth in Individuals With Twin Pregnancy and Short Cervix: QUAD-P Twins.
Trial report in The Australian & New Zealand journal of obstetrics & gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy.The Cochrane database of systematic reviews · 2017Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundBoth twin pregnancy and short cervix are risk indicators for preterm birth. Cervical pessary and progesterone have been suggested to prevent preterm birth. A randomised trial was conducted in individuals carrying twins with cervix below the 25th centile (less than 38 mm).
methodsWe conducted a single centre open-label randomised clinical trial at Monash Medical Centre in Victoria, Australia (Trial registration number: ACTRN12616000875404). Individuals with a twin pregnancy and mid-trimester (16
resultsBetween 2 December 2019 and 27 July 2023, 159 individuals were screened, of whom 66 had a cervical length ≤ 38 mm, and 34 were randomised to Arabin pessary (N = 16) or progesterone (N = 18). One woman in the progesterone group withdrew consent after randomisation. The study was halted as studies elsewhere had indicated no benefit from pessary. Composite adverse neonatal outcome occurred in 41% (13/32) of the neonates in the Arabin pessary group compared with 29% (10/34) of the neonates in the progesterone group (risk ratio [RR] 1.38, 95% CI 0.71-2.69). Delivery before 28 weeks occurred in 19% (3/16) and 5.9% (1/17) (RR: 3.19, 95% CI 0.37-27.58).
conclusionIn individuals with a twin pregnancy and a short cervix, we could not report benefit from cervical pessary over progesterone.
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