ArticleScience progress
Naples prognostic score shows potential complementary value to agatston scoring in patients with very high coronary calcium burden: A single-center hypothesis-generating study.
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Abstract
ObjectiveThe Agatston score quantifies coronary artery calcium (CAC) but shows limited specificity for obstructive coronary artery disease (CAD) with extensive calcification. The Naples Prognostic Score (NPS) integrates inflammatory and nutritional parameters. This study evaluated NPS performance alongside Agatston scoring.MethodsThis is a retrospective, single-center study that analyzed 426 stable angina patients undergoing coronary CT angiography and invasive angiography at İzmir City Hospital in 2024. Agatston and NPS scores were calculated from routine parameters. Obstructive CAD was defined as significant lesions. Performance was assessed using ROC analysis and multivariate regression.ResultsAmong 426 patients (age 61.7 ± 9.5 years, 63.4% male), 277 (65.0%) had obstructive disease. Obstructive CAD patients showed lower HDL (
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