ArticleJournal of the American Heart Association2026
Effects of Intrathecal Magnesium Administration on Neurologic Outcomes in a Porcine Model of Asphyxial Cardiac Arrest.
Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
backgroundMagnesium mitigates several mechanisms involved in secondary brain injury after cardiac arrest. Because systemically administered magnesium crosses the blood-brain barrier poorly, it may be unsuitable for early post-cardiac arrest neuroprotection. We tested whether intrathecal magnesium (IT-Mg), which bypasses the blood-brain barrier, improves neurologic outcomes in a porcine model of asphyxial cardiac arrest.
methodsTwenty-four pigs underwent asphyxial cardiac arrest and cardiopulmonary resuscitation. Thirty minutes after return of spontaneous circulation, the IT-Mg group received 75 mg of magnesium via cranial intrathecal catheters; the control group received no IT-Mg treatment. Animals were observed for up to 72 hours post return of spontaneous circulation.
resultsSurvival duration and cumulative survival did not differ significantly between groups. In controls, the mean amplitude-integrated electroencephalography amplitude remained depressed for 24 hours, whereas it increased in the IT-Mg group (group×time interaction
conclusionsIntrathecal administration of magnesium after return of spontaneous circulation mitigated histologic injury and improved neurologic function in a porcine model of asphyxial cardiac arrest.
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