Evidence map›Paper›PMID 41878854›Full record

ArticleJournal of the American Heart Association2026

Air Pollution and Incident Cardiovascular Disease: Modification by Genetic Susceptibility and the Mitigating Role of Physical Activity.

Wei Liu, Linling Yu, Meng Yang, Xuefeng Lai, Da Shi, Hao Wang, Wei Liu, Jiahao Song, Xiuqing Cui, Weihong Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei Liu *Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.ORCID 0000-0001-5163-9742
Linling Yu *Department of Public Health, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.
Meng Yang *Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.ORCID 0000-0002-1466-0769
Xuefeng LaiDepartment of Occupational and Environmental Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Da ShiAgricultural, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences University of Alberta Edmonton Alberta Canada.ORCID 0009-0006-0234-9654
Hao WangDepartment of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Wei LiuMedical Big Data and Bioinformatics Research Centre First Affiliated Hospital of Gannan Medical University Ganzhou Jiangxi China.
Jiahao SongDepartment of Occupational and Environmental Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.
Xiuqing CuiNational Institute of Environmental Health Chinese Center for Disease Control and Prevention Beijing China.ORCID 0000-0001-7281-3789
Weihong ChenDepartment of Occupational and Environmental Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.ORCID 0000-0001-8689-7311
Bin WangDepartment of Occupational and Environmental Health, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China.ORCID 0000-0002-7166-0482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe interplay and joint effects of air pollution, genetic predisposition, and physical activity (PA) on incident cardiovascular disease (CVD) remain poorly understood. This study aimed to examine the associations between various air pollutants and CVD and assessed potential modification by genetic susceptibility and PA.

methodsThis prospective cohort study included 330 481 UK Biobank participants without baseline CVD. Annual average concentrations of particulate matter <2.5 μm (PM

resultsDuring a median follow-up of 11.8 years, 45 565 incident CVD events occurred. Individual pollutants and a composite air pollution score were positively associated with CVD. Each 5 mg/m

conclusionsLong-term exposure to ambient air pollutants was associated with higher CVD risk, particularly among those with high genetic susceptibility. Although PA was protective overall, its benefit was attenuated under higher air-pollution and genetic burdens, underscoring the importance of integrating environmental control with individualized prevention strategies.

Indexed as

Air PollutantsAir PollutionCardiovascular DiseasesEnvironmental ExposureExerciseGenetic Predisposition to DiseaseAgedFemaleGene-Environment InteractionHumansIncidenceMaleMiddle AgedParticulate MatterProspective StudiesRisk AssessmentAir PollutantsParticulate Matterair pollutioncardiovascular diseasegenetic susceptibilityinteractionphysical activity

Identifiers

PMID41878854
PMCPMC13279189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.